crystallatticed - stem🤗🤗

crystallatticed

stem🤗🤗

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Latest Posts by crystallatticed

crystallatticed
8 months ago

people who work/study in quantitative bio-adjacent fields, rise up. computational neuroscience where you get to see someone's thoughts in feelings in graph form??? so cool. biophysics where you can pass blood plasma through an electric field to determine whether a patient has cancer or not?? unbelievable. biomedical engineering where you can literally build a device to pump someone's heart and be the difference between their life and death??? oh my god. disease modelling, being able to predict AND prevent communities being affected by disease on a large scale through your analysis of data??? i love science

crystallatticed
8 months ago

look, I know I've talked about this essay (?) before but like,

If you ever needed a good demonstration of the quote "Any sufficiently advanced technology is indistinguishable from magic", have I got an exercise for you.

Somebody made a small article explaining the basics of atomic theory but it's written in Anglish. Anglish is basically a made-up version of English where they remove any elements (words, prefixes, etc) that were originally borrowed from romance languages like french and latin, as well as greek and other foreign loanwords, keeping only those of germanic origin.

What happens is an english which is for the most part intelligible, but since a lot everyday english, and especially the scientific vocabulary, has has heavy latin and greek influence, they have to make up new words from the existing germanic-english vocabulary. For me it kind of reads super viking-ey.

Anyway when you read this article on atomic theory, in Anglish called Uncleftish Beholding, you get this text which kind of reads like a fantasy novel. Like in my mind it feels like it recontextualizes advanced scientific concepts to explain it to a viking audience from ancient times.

Even though you're familiar with the scientific ideas, because it bypasses the normal language we use for these concepts, you get a chance to examine these ideas as if you were a visitor from another civilization - and guess what, it does feel like it's about magic. It has a mythical quality to it, like it feels like a book about magic written during viking times. For me this has the same vibe as reading deep magic lore from a Robert Jordan book.

ling.upenn.edu
crystallatticed
8 months ago
|| Radio ||

|| Radio ||

|| Radio ||

Requested plot points? ☑️

Circa: early February 1944

Immediate previous fic: Favorite Escape

Summary: when your hodge podge radio won’t work, who should ya call? Probably the flight engineer

Warnings: usual universe warnings apply, 18+ but nothing very alarming really happens in this one, references to others are made, some potential slut shaming in the beginning if ya squint? perhaps some queer baiting but it’s the Buckies rolling around on the flooor, they’re one massive queer bait lbr, it’s not me. Also. My shit Crystal Radio making descriptions- don’t come for me I haven’t made one and I spent five hours falling down a rabbit hole as to how the guys made them in the camps and at the end of the day I said: screw it! And went with one of the Brit’s scenarios 🍻

Edited only by my tired little eyes, full warning and have mercy 💋

Also, just a note I feel compelled to make- this fic centers around women in the army, in a war, which they’re spending under dire conditions in a POW camp. Yes there is love here, there is also hierarchy and discipline and the enforcement of that does not make one character or another necessarily callous or less loving. They are their ranks first and foremost as all signed up for.

“They’re forging papers, you know.” Maureen broached the topic to Egan one day, late February and when her cheeks were still bruised from Ida’s book.

Bucky paused his tracing of a map, sooty finger trailing along a river with the same incomprehensible name as its twin running parallel, he didn’t know anything about papers or anyone making them and she knew that. “Who?”

“Good ones. Identification, passports.” She enumerated.

“Who?”

“The Poles. The ones with the-“

“-the liquor.” he finished for her, remembrance and condemnation heavy in his wry tone. “The ones you stayed out all night with.”

“Stayed long enough for them to get drunk enough to show me.”she replied, without heat, which was surprising.

“Some grand plan of yours, huh?” He bit back a laugh, it was a fine way to cover her ass for being insubordinate. It was a way he’d likely try if he was in her place.

“No.” she swore instead. “Just luck, I happened to see them. They got careless. Maybe an answer to all Jack’s prayers.”

“Yeah. Anything to give that rosary a break.”

“Yeah.”

“You asked them?”

“What for?”

Bucky regarded her with thinning patience but something kept him from snapping, the feeling of a riddle still to be solved. “For some papers.” he clarified, measured and intent, she knew how much easier that would make their plans for Ida.

Maureen shook her head, glancing down at her twisting hands, “I didn’t want to-“ her mouth twisted too, “-I wanted to ask a superior first.”

Bucky considered that for a moment, slightly touched at her newfound wisdom, “Why not ask Buck?”

She shook her head again, auburn hair curling under her chin just so, even here in the stalag she had some traces of the old charm. “He’s got too much to worry about for me to be bringing in hypotheticals.” she was so upset by something she would not even meet John’s eye and he felt a slice of remorse for how he hadn’t even noticed the ground down change in her since she got here, his drinking buddy and the soft fleshed rival of merry old English days was a gruff and battered and sullen woman; being a red blooded American male, he regretted that dismal change. “And I'm worried about what to bargain with. What can I promise? We haven’t got much and I don’t have— there’s not much anyway, but what we’ve got I didn’t wanna promise. Not without-“ she still hadn’t met his eye, he tracked hers; a furious roving of pale blue back and forth across the floorboards and it made Bucky itch.

“Who signs these papers?” Bucky asked, thinking the logistics through, knowing she’d perk up if he brought them up.

“Haven’t a clue. Maybe they haven’t figured that part out yet. I don’t know. I just know they’ve got papers.”

“Good ones.”

“Yeah.”

“We haven’t got much.” he agreed, clicking his teeth in thought, “What’d you give them for the liquor?”

“They just invited me.”

“Didn’t have to lend a hand or nothin’?” he balked and Maureen threw him a glare that seemed more hurt than rage, and chastened by a voice inside that sounded much like his mama’s, he amended with sheepish humor, “Hell, feel like lending a hand myself these days, if it’d get me a whisky.”

Her gnarled fist curled white in her lap, she managed hoarsely, “They just wanted to talk about home. To someone who hadn’t heard about it a million times before.”

“They got cigarettes?” he asked.

“As most common payment for their booze -they’ve got enough to insulate their shack three deep.”

“Cigarettes won’t cut it then.”

“I’ve been thinking.”-

“Yeah?”

“The radio. I’m the only one who doesn’t think it’s worth the risk but, I know, it doesn’t matter, it’s happening. Gale’s going to keep trying. And if it works-“ she rubbed at her eyes, tired and unsure, “-that’s quite the bargaining chip.”

Bucky nodded slowly, eyes narrowing as his smile grew a touch broader, “News of the outside world.” he was half in agreement, “Buck asked for a week. Been four days.”

“He’s stumped.” Maureen retorted instantly. “And he’ll stay that way and he’ll go nuts and you’ll go die going over the fence and then he’ll have no reason left not to die too.”

Bucky whistled, low and chiding, “You’re full of rainbows today, Candy.”

“You know who he oughta ask.” she shook off the barb. “But he won’t. And I don’t want him risking it for this thing anymore than anyone else, but you all want it so bad, and they’ll shoot us for it if it works or not. I’m not asking her. But you would. Might as well get shot for it working, right? Isn't that what you said yesterday? You know who he should ask.”

Bucky’s keen eyes showed the moment it dawned on him, his eyebrows shot up and his mouth sagged and he ran a weathered hand over his face, “Awww shit, Candy.” came garbled behind his palm. “Ah shit.” he said again with conviction as he shoved the hand into his pocket, wretched acknowledgment of her point clear on his face.

“I didn’t want to suggest it, told Ida it’s a fucking dangerous thing and I’ll never forgive if— but you all—“

Bucky grounded aloud, “Nah, nah she’s -Lu would solve it.” he muttered, shushing her. “Demarco really pummeled you the other day, huh?” he added, and that got her to meet his eye, she looked spooked and a little incensed, “Saw him fuckin’ you up behind B compound but sheesh, s’like he hollowed you out worse than a jacolantern; yer shifty as hell.”

“He-“ Maureen still felt like blanching at the memory of Benny’s terribly correct opinions, his disappointed eyes and his fist full of her flight jacket asking her what in the living fuck was wrong with her besides a concussion, a sick childhood and an ever nauseating jealousy of Buck Cleven’s paternal time and effort, “-he had some admonitions. After…after the other night.”

Bucky hummed, shitty smirk taking up residence on his face, “How ‘bout that.”

“I’m gonna be better.” she muttered and Bucky felt for her, could almost taste the echo of his identical and hollow determination to climb the mountain of bad habits when weak from spuds and pneumonia. He told himself the same every morning and fell into bed condoning his failure every night, like a ritual.

“You’re gonna get us those papers.” he corrected, shoving off the wall to come near her, give her the full Major treatment and maybe a friendly hand, “And you can promise your drinkin’ buddies news from the radio.”

Maureen nodded in understanding, no joy or animation left in her green eyes. She used to enjoy a bit of subterfuge, now she only felt hollow misery at the thought that she'd dragged Lu into this, too. This risk she hated so much and yet no one cared. Lu would be glad to be dragged in, it’s true, she was itching at the chance to be useful and to make Gale proud, it’s how the girl was wired. It’s how most girls were wired, Maureen supposed, desperate to make Gale Cleven approve. Lu’s enthusiasm wouldn’t make the sight of her being made to kneel in the mud and have a bullet put in her head any easier, wouldn’t make Maureen feel any less responsible for it when her lifeless body thudded to the earth.

All that lovely goodness stamped out.

Over a radio.

Bucky’s hand felt too hard and too big on her shoulder. He had gone before the vision cleared, mud and wire and the freezing main square at Ravensbruck fading back to the musty bunk room. Maureen shook herself and stood up to make herself somehow appealing, reamniante some semblance of the cheerful rashness that had led her to the Polish combine in the first place: she found it hard to inspire. She’d like to count that a victory but she knew better, she wasn’t reformed she was just tired.

A washed face and a fake smile and the promise of news from outside would have to be enough to bank all their risks on, it would have to be.

“Crank,” she greeted the man in the hall, flashing him clean, water brushed teeth and her gentlest, freshly soot lined eyes, “I’ve been tasked by Major Egan with an errand, spare a minute to babysit me?”

__________________________________

Bucky finds Buck Cleven in his own bunkroom, Demarco outside on watch and that’s all Bucky needs to know to guess the radio is out and Buck’s working like a fiend yet again to make it work. Sure enough, he’s hunched over the table with it, mittened hands shaking from cold and exhaustion and a sheen of sweat on his forehead despite the paltry sweater he wears.

Bucky walks in and Gale gives him a soft, acknowledging glance before continuing to his work. Bucky takes up his usual place behind Buck’s left shoulder to watch and Buck, being used to it, goes on.

“My little Kriegie Marconi, huh?” Bucky allows the nagging impulse he has felt for weeks while standing in this position to finally exert itself, and his forefinger lifts and swirls in the curling gold strands of hair at the nape of Gale’s neck, his friend almost bolts away but then seems to choose a prey’s tactic and just stills, goes very still and Bucky scritches the scalp beneath his grab in assurance he don’t meant anything by it. He doesn’t think he does, at least.

Gale, wary and with a voice close to mechanized it’s so stilted, inquires with ever-present politeness, “You alright Bucky?”

It’s better than that whole ‘major’ business; getting called Major as if that meant shit anymore. “Yeah, ‘course I am.” Bucky rakes his fingers through the hairs there at the nape of that dainty neck, scritches the scalp with all four of his main ones, and uncovers a white long scar sliding round once he lifts the hairs there. “Why wouldn’t I be? Gonna be a father soon.”

Buck does jerk then, away from his touch and wheeling his chair around to glare at Bucky; it’s an impressively executed little pirouette and John misses the feel of his warm neck and oil soft hair. “Jesus John.” he reprimands.

“We’re gonna get outta here Buck.” John swears, he’s so sure of it because he cannot in all his thinking and predicting ever imagine a scenario where they don’t, and he chooses to think it’s not delusion but a good omen. “Ida’s gonna have that baby and when it’s safe we’ll all meet up.”

Gale is looking at him like he’s his own father again, Bucky knows that look, it always makes him equal parts ashamed and desperate, “Jus’ like that.” Gale mocks in a husky gust.

It’s devastating, and it’s intended to be, and Bucky could bear that with better humor if he could still touch Gale and his hair. “Just like that.”

Gale hums and it’s a mean sorta vocalization that makes Bucky’s heart thud and his skin prickle hot, it’s the kinda noise you kiss off a person, he thinks, but it’s Buck and so he doesn’t know what to do with it. “It’s gonna get you killed.” Buck is saying instead and Bucky lets him, “I know you all think she’s cracked up and maybe she has but it wouldn’t hurt to listen to Kendeigh sometimes when she’s tellin’ ya shit that a five year old could accurately guess, -goddamn it.”

His voice rose to a strong rage by the end and Bucky takes a chair opposite him, sick of standing there like a dumb dog waiting for his scolding to be over. “So what.” Bucky challenges him, “We just wait around and Brady pops out a child and the krauts let us keep it and it’s our new mascot and we all sing zippidy doo da, huh? Huh, Buck?”

Gale’s hands fell away from his face with a slam to the table, a shocking degree of anger showing for a split second and it gave Bucky an odd degree of gratification. “I jus’ want you to find a plan with better odds.”

Bucky sniffed and leaned forward, went in for the kill and Gale was looking at him like he expected it, like it was his turn to play daddy to everyone here and Gale for once was so beaten down he wouldn’t just allow the changing of the guard, he was close to angry at its lateness. It made Bucky’s heart thud.

“I’ve been listening to Kendeigh.” Bucky refuted briefly, “And we’ve got a plan.” Gale gave him a tired look of encouragement to go on, “How long’s it been since you slept? Huh, well, we got a plan. Practically perfect, or it will be, just need the radio.”

“Ain’t giving this away.” Gale said, “Not for anythin’, even useless.”

Bucky patted the table top in easy assurance, if he could have reached Buck’s thigh, he’d have patted that instead, “No, no, don’t need to give it away, just need it to work. So,” he softened his voice and his eyes tightened, “I’m callin’ Lu in.”

Oddly, Gale does not fight it. Not aloud, at least. There’s an anguished look of hate on his face and Bucky mirrors it. It’s for this place and the fucking awful choices they have to choose from every goddamn day.

“You run this by Ida?” is all he asks.

Bucky pops his flaking lips audibly, “What, need us both gangin’ up on you to agree? She’ll sign off. Smith’s an officer. Gotta remember that sometimes, Buck.”

The way his Buck swallows hard and dry contradicts his words, “I do remember that.”

“Really?” Bucky’s mouth gives a soft smile of doubtful incredulity and Gale’s mimics it, mournful but a smirk all the same, “Feel like she should answer to ‘Gale’s Baby’ these days. Lieutenant Smith who?”

Gale scoffs, “Careful now.”

“No really, she’s an officer and she wants to be treated like one. It’ll do her good to have work. Her kinda work.”

“Could get her killed.”

“Layin’ in her bunk could do that.”

Gale grunts, its sounds like an agreement.

“So I say Lieutenant Smith gets put on radio detail. Like her goddamn job description suggests. Huh, yeah?”

“Yeah.” Gale lets out a shaky agreement.

“Aaaaand,” Bucky draws it out as he rises again and saunters over to Buck who is ready for him and loose this time, “how bout I go back to bein’ the one you’re frettin’ ‘bout all the time. Got me almost jealous of the girl. How ‘bout I do. Huh?”

Gale’s scoff is fond as anything as he looks up at John with cheerful derision, “And you ‘bout to be a father? Make me an old man? Fuck no, ya looney.”

“Alright.” Bucky concedes with hands up in surrender before lurching forward and grasping Gale’s rickety chair back by its wobbly spokes and hefting it partially off the ground, beautiful and outraged prude of an occupant still seated in it, “Then I’ll play daddy and put you to bed, how ‘bout that.”

“John Egan for fucks sake-“ Gale’s fists pounded on the meat of his shoulders and his outraged protests wafted against Bucky’s neck and his jabbing knees collided with the meat of his thighs and Bucky hadn’t felt so close to him or so happy to be alive since England.

“Major sir, the hell is goin’ on?” Demarco’s tame inquiry from the safety of the doorway made them both lose their grapple and they collided together onto the floor, bunk bed barely missed by their heads and the hapless chair mixed up between their limbs.

Bucky grinned, hip sore from his fall and kidneys suffering from Buck’s trapped elbow there, “Puttin’ Goldilocks to bed.” he replied.

DeMarco processed that and the scene before him with grave sobriety before saluting lazily and turning to go, “Right on, sir.”

John did his best to rise up without further pinching Gale who was indeed trapped beside him and beneath him, chair legs wound between a lanky human leg in a puzzle that Bucky realized might take some caution to untangle without harm. Strangely, Buck wasn’t moving, he was just looking up at him like a cat would their clumsy master who has done somethin’ stupid which was a surprise to neither. It was so innocuous a look and so nostalgic, it winded Bucky with the realization he hadn’t seen it in ages, just as he hadn’t felt his boney ribs against his own and the feel of his elegant hands yanking him around in a fight. This miserable place really was stomping out the glow in the best people.

“Ya know Buck,” he ventured, clearing his throat for extra casualness, “I’ve missed you.” When Gale only kept looking up at him, perfect porcelain face with its unsettling scars and wary eyes without a lick of storm in them, John Egan grabbed his shovel and dug his own grave a little deeper, drug a finger down his cheek. “Missed all this.”

Bucky didn’t know what he meant by “this” but it felt safer and worse all at once, since he did miss Buck but he and Buck never used to hang out on floors with a chair as chaperone. Mercifully, Buck neither points that out nor moves away, acting very much like he needed to heaped on the floor with Bucky and a stray chair every bit as much as John did. Like it’s doing him good.

“And you couldn’t’ve jus’ said.” Gale murmurs with the softest eye roll of the century and Bucky feels like beaming and it must show in his face so strong and bright after a sunless winter that after a flash Gale’s cheeks flame from it and he averts his eyes.

“I dunno Buck, could I?” Egan asks one blushing cheek and Gale hasn’t got a good reply for that, so they just lay there on the floor.

“Go on now, get off me.” Gale doesn’t shove at him, he presses his hand to John’s forehead like he would a dog and John goes, obedient as one.

———————————————————————-

They found Lu with Murph and Benny and Brady, measuring out what seemed to be lot lines between Love Shack #9 and the next combine, boot scuffed perimeters already visible in the light snow and drawn in a decently tidy rectangle. There were guards loitering nearby, nosey as always with their cigarettes and their antsy dogs anytime someone did something out there besides piss or pace or stare at the fence.

“What’s all this?” Bucky inquired cheerfully, coming up to them with Gale, bundled and shivering behind him.

Benny looked up from tilling a furrow with his boot, right where Lu’s mittened finger pointed out. “It’s for the garden. S’posed to be spring before long.”

“A Chicago man oughta know better, Benny.” Egan snarked.

“Need us?”

Bucky sniffed, a casual set to his body that belied his quest, “Just the little one.”

Smith promptly looked startled, then eager. “All well Majors?”

“Need your advice on the color of my cufflinks with this suit.” Bucky extended his arm and beckoned her, “C’mon back in for a minute. One of you too, need a watch to go with the cufflinks.”

———————————————————————

With Benny on guard, Brady and Kendeigh having excavated the radio’s shell from the floorboard and table leg in which it resided, the Buckies stood over Smith’s small frame as she sat at the table and inspected the simplistic device with keen eyed appreciation for the construct.

“It’s really marvelous.” she assured Cleven, running her fingers over the carefully coiled wire and precarious pin.

Gale didn’t even crack a smile. “What’s wrong with it?” he asked instead.

She shook her head, a frown gathering. “Never made one-“ she cautioned.

“-but you get the idea.”

“Yes sir, I do.”

“So what’s wrong.”

Lu ran her fingers over the wire, again and again, the dusty metal not insulated, just bare copper, likely stripped from somewhere. It reminded her of early days as a cadet when they threw chicken wire mixed with hydraulic lines at herself and her fellow rookie engineers and told them to sort it, testing to see if they knew which was which. It had been so rudimentary she had wanted to laugh until she realized others were being flunked.

This was so basic she was stumped.

“Take your time, Lu.” Bucky spoke up after a burdened pause during which she could almost feel Major Cleven breathing down her neck.

“Candy, can I try with the headphone?” she asked at last, frustrated and out of her element, just a few months out of a plane and she had already lost her touch.

Maureen passed it over and Lu pressed it to her ear, not to discern what was quite obviously radio silence, but to imagine the whole process in reverse, track it down the cord all the way to the base, each possible breakdown of the conduction.

She fingered the ramshackle diode with burgeoning suspicion. “What’s your crystal?”

“That’s just…lead.” Cleven muttered.

“From?”

“Ground pencils.” Bucky supplied cheerfully.

Smith bit her lip, “We need sulfur added. Lead won’t conduct on its own.” She figured Cleven knew that, the grim and unmoving set of his mouth suggested so.

“Just- sulfur?” Maureen asked.

“If I had sulfur we could add it to the lead dust, ignite it and-“ Smith grinned at Kendeigh, knowing that she alone may have shared her enjoyment of a small conflagration from time to time, “burn it down and you’ve got something close enough to Galena. Just need a pinch of it should work.”

Bucky shoved his hands in his pockets and surveyed the mostly morose room. All except for the two girls grinning at each other over the hypothetical of a little chemistry experiment in a highly flammable wooden combine.

“We’ve got sandy soil.” Buck’s contemplative drawl spoke up, “Dunno if we could extract enough pure sulfur.”

Maureen stared back at Egan instead, “Other sectors have gotten portions of kits, chemistry kits, radio kits, they’ve been smuggled in with all sorts of stuff. Inside of a violin, oat bags. Nothing to fully build something. They might have sulfur. I could make inquiries and- well, Jack could pick it up next time the band goes over C compound to entertain the poor Aussie bastards.”

“How do you kno- nevermind, actually. Nevermind.” Bucky broke off, “Alright. Sure, why not. Ya sure that’s it?” he asked Lu once more.

She gave a helpless little shrug. “Gotta be. Or the wire’s dirty. Where’d it come from anyway?”

Gale gave Bucky a long suffering look as Bucky seemed to swell a couple inches and bounce back on his heels at the mention of his scrounging prowess. “The lamp.” he nodded above them all.

Jack Brady scoffed, short, clipped, betrayed, “That why it cuts out all the time? Strobed us so bad last night -thought the room was possessed.”

“Sacrifices Jack, sacrifices.”

———————————————————

Benny had hauled in enough water buckets to elicit some negative attention from the guards, and when the inspection came the inmates of the Love Shack insisted the drenched floors and table of the Majors’ barracks were due to sanitation post regurgitation. At night, with only one stolen torch light from Combine 15 to illuminate the endeavor, a basin of water beneath a smaller bowl in which lay their precious and recently procured ingredients, a science experiment began. The Majors and Ida gathered round, all looking as ghastly and spectral in the light of the flashlight as Brady’s fake ghost. It held the thrill of a bonfire night except for the stakes, which all in the room did their best not to dwell on.

“Zippo, Candy.” Lu gave the word and Maureen, with only the protection of Ida’s bent aviators to keep from a scorched cornea, flicked on her lighter and set the mixed powders ablaze.

It flamed up high and smelly, making Benny gag and mutter something about Meatball’s gas to a tittering Brady, and then died down to a yellow smoking ember.

“We should let it sit.” Lu surmised with a squeeze to Maureen’s only somewhat singed hand, her big dark eyes surveying the burnt bowl and their smoking experiment with glittery excitement at the possibility of success, “Let it cool, settle, maybe strain it. Can you get me a net? Oh Candy come now, get me a strainer?” she begged with a laugh as Maureen rolled her eyes at the idea of yet another trip to the Stalag Market for the most random items imaginable. If they hoped to not be suspicious, they’d need better lies or more money.

“How about cheesecloth?” Kendeigh tried not to grin indulgently- and failed- in the face of Lu and having recently been allowed to set something on fire

Lu kissed her cheek. “Cheesecloth would be perfect.”

In the end, cheesecloth did indeed prove perfect, and amongst the burnt dust of the combined minerals was a gritty little pinch full of the needed crystals. Or so Lu said, Gale agreed but the crease between his brows hadn’t lifted for two days; Bucky’s fingers had begun to twitch in antsy need to manually smooth them out. He imagined Maureen felt the same but she hadn’t said, uncharacteristically forbearant now she had some job to keep her sane. Even if it was playing fetch for Lu.

—————————————————————

“Well, this is it.” Gale muttered when the watch had been set once more, Murph and Hambone on the steps, Crank inside, Brady at the door, Benny at the window. Even Major Clark had joined them in the barracks for this final try and Lu’s cheeks were maroon from the attention even as her deft hands steadily pressed her concoction beneath its intended rod.

“Pass me the pliers, sir?” She asked and for a moment, the teacher became the apprentice and Gale fetched her the stalag forged tool, rudimentary like everything here yet the gripped and pulled and lifted same as the pliers back home. “You could check your look in this wire’s reflection.” She complimented Gale’s buffing of the copper wire.

He shrugged in turn. “Didn't wanna leave anythin’ to chance. That it?” he asked as her hands stalled and she surveyed her work.

Lu nodded solemnly. “Yes sir.”

Gale picked up the headphone from in front of him on the table like it was a gun he was about to bring to his head. “Here.” He extended it to her instead, “S’right, it was your job, you should be the first. Cmon.”

Despite her voiceless protest he pressed the headphones into her hands and Lu, never knowing how to disobey an officer, folded immediately.

For a good ten seconds everyone in the room held their breath as Smith pressed the headphone to her ear and gently wiggled the clothespin along the wire, searching and tuning, her face holding that old peaceful concentration they hadn’t seen since the last mission. She was at home with her mind tuned to another dimension. The pilots in the room knew that look, that was the look of someone at home with something that terrified them all the same, the gut swooping feeling of clearing the take off and sledding along the tops of the clouds. Wrong and strange and utterly incomparable to others, it was the closest to home one’s mind could be. Lu belonged somewhere on those electric currents and searching them out was like finding oneself again.

Then at last, Lu’s eyes sharpened out of their dreamy haze of concentration and she said, gentle as always, “It’s the BBC sir.”

💋 Hope you enjoyed! Feedback is a writer’s lifeblood, please feel free to scream in comments or the inbox, I love it and wanna hear it all. Trust me, nothing is “too dumb”. Your thoughts mean the world to me.

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crystallatticed
8 months ago
In a First, a Prosthetic Limb Can Sense Temperature Like a Living Hand
Smithsonian Magazine
The advance may help users feel a greater sense of human connection through touch

Amputees’ hopes to experience the feeling of human touch using their prosthetics are becoming closer to reality. Now, new technology is allowing them to feel temperature—even in limbs that are no longer part of their bodies. For the first time, a functional artificial limb has been fitted with fingertip sensors that allow an ordinary prosthetic hand to sense and respond to temperature just as a living hand does. The device provides a realistic sense of hot and cold in the missing “phantom” hand by delivering thermal information to nerve areas on the amputee’s residual limb that the brain believes are still connected to the missing hand. The MiniTouch, described in a study published Friday in Med, was created with affordable off-the-shelf electronics, requires no surgery and can be fitted to existing commercial prosthetic hands in a matter of hours.

Continue Reading.

crystallatticed
8 months ago

Tony's surgeries in the cave: Part 3. Second Surgery

Why the second surgery was necessary: Part 1, Arrhythmia, Reactor, Part 2

What was done:

Removal of the electromagnet.

Sternectomy - partial removal of Tony's sternum.

Removal of some chest and abdominal muscles (some partially, some completely).

Removal of parts of at least 4 ribs on both sides together with parts of attached muscles.

Yinsen may or may not have removed the thymus.

Tony's heart was slightly shifted back in his chest cavity.

Implantation of pacemaker-ICD electrodes running from the bottom of the reactor housing to the heart (This could be done either directly through the chest cavity outside the heart, or through the subclavian vein into the heart).

Removal of parts of Tony's lungs/lungs moved to the sides.

Displacement of blood vessels in Tony's chest.

Displacement or removal of lymph nodes in the chest. In case of removal - replacement with an artificial system connected to the reactor housing.

Implantation of the titanium reactor housing, its attachment to the parts of the sternum that were not removed.

Connecting the housing to the ribs using rib clamps.

Attaching the reactor with the pacemaker to the housing.

Suturing muscles and tendons to the reactor using surgical/biological mesh.

Closing the wound with polyester cuff around the housing where it meets the skin.

Suturing the sternectomy incision.

How do we know this actually happened?

In addition to the reasons stated in Part 1:

After the first surgery, we don't see the reactor housing in Tony's chest. The electromagnet is bolted to the sternum and, unlike the reactor, cannot simply be temporarily removed from the chest.

Tony's Surgeries In The Cave: Part 3. Second Surgery

As you can see below, unlike the electromagnet, the reactor housing is complex, clean, made of titanium and designed specifically for the arc reactor.

Tony's Surgeries In The Cave: Part 3. Second Surgery

Remember about internal organs - you can't just make a hole and put anything in there, no matter how deep it is. You'll need to remove or displace something.

In the scenes below we can see a fresh sternectomy scar after the reactor was implanted. The scar looks different every time, and sometimes it disappears completely thanks to makeup artists. There is not a single scene with this scar before the reactor.

Tony's Surgeries In The Cave: Part 3. Second Surgery
Tony's Surgeries In The Cave: Part 3. Second Surgery
Tony's Surgeries In The Cave: Part 3. Second Surgery

As I mentioned in The Cave timeline (March 1 - April 12), several weeks passed between the successive scenes: Tony finished working on the reactor and showed Yinsen the armor blueprint > the security camera scene and the backgammon scene.

The two weeks between the first surgery and Tony waking up would not have been enough time to recover from the trauma of the reactor implantation. Tony instantly jumps to his feet and is able to raise his arms above his head and hold a car battery - nope, that's absolutely unrealistic.

The Ten Rings would not allow them not to work, but we see them playing board games. Post-op recovery explains it.

crystallatticed
8 months ago
Title: Classical Periodic Table.

[A periodic table with only the elements of Water, Earth, Fire, and Air. Air takes up the spots of all the gases, Water, the spots of Mercury and Bromine, Fire all the radioactive elements with very short half lives, and Earth the rest of the table].

Personally I think mercury is more of a 'wet earth' hybrid element.

Classical Periodic Table [Explained]

Transcript

[Title text: Classical Periodic Table]

[A diagram in the shape of the periodic table of elements is split into labeled colored regions. Each region is labeled with a large letter over a word in smaller letters.]

[The regions and colors are as follows:

A: Air: light blue: the first element and the upper-right of the main body, which includes noble gases, halogens and some non-metals.

W: Water: dark blue: two separated cells in the main body.

F: Fire: red-orange: the bottom stripe of both the main body and the separated section.

E: Earth: brown: everything else, the majority of the diagram.

]

crystallatticed
8 months ago
crystallatticed - stem🤗🤗
crystallatticed
8 months ago

The whole “scientists use big words on purpose to be exclusive” is such a bunch of anti-intellectual bullshit. Specific and concise language exists for a reason; you need the right words to convey the right meaning, and explaining stuff right is a hugely important part of science. Cultures that live around loads of snow have loads of words to describe different types of snow; cultures that live in deserts have loads of words to describe different types of sand. Complex language is needed for complex meaning.

crystallatticed
8 months ago
[A periodic table with regions labeled facetiously, such as hydrogen being labelled "slightly fancy protons", the platinums labelled "[dollar signs]", Lithium and Beryllium being labelled "weird dirt", and the Noble Gases being labelled "lawful neutral".]

Cesium-133, let it be. Cesium-134, let it be even more.

Periodic Table Regions [Explained]

Transcript

[A periodic table with regions labeled.]

[Hydrogen:] Slightly fancy protons [Lithium and Beryllium:] Weird dirt [Group 1 & 2 metals, Periods 3-4:] Regular dirt [Group 1 & 2 metals, Periods 5-7:] Ends in a number, let it slumber ends in a letter, not much better [Left side of the transition metals group:] Boring alloy metals Probably critical to the spark plug industry or something (but one of them is radioactive so stay on your toes) [Most of the top row of the transition metals + aluminum:] Regular metals [Below the rightmost "regular metals" - the "ordinary metals" and some transition metals:] Weird metals [The platinum group:] $$$$ [Boron:] Boron (fool's carbon) [Carbon, Nitrogen, Oxygen, and Phosphorus:] You are here [The Halogens:] Safety goggles required [Noble Gases:] Lawful neutral [Iodine and Radon:] Very specific health problems [Ordinary metals and metalloids - Arsenic, Antimony, Tellurium, Thallium, Lead, Bismuth, Polonium] Murder weapons [Astatine and Period 7 from Rutherfordium onwards:] Don't bother learning their names - they're not staying long [Lanthanides and Actinides:] Whoever figures out a better way to fit these up there gets the next Nobel Prize

crystallatticed
8 months ago

leaving a three hour lab be like:

what time is it? why is it dark outside? where did the sun go?

I'm starving.

I'm never doing that again (literally has the same lab scheduled the following week).

crystallatticed
8 months ago
NASA astronaut Deniz Burnham, a white woman, poses for a portrait at NASA's Johnson Space Center in Houston, Texas. She looks directly into the camera as the light highlights her blonde hair. Credit: NASA/Josh Valcarcel

Deniz Burnham

A former NASA intern, Deniz Burnham started her career as an engineer on an oil rig in Prudhoe Bay, Alaska, and went on to lead operations on drilling rigs in Canada, Ohio, and Texas. https://go.nasa.gov/3wDpfBo

Make sure to follow us on Tumblr for your regular dose of space!

crystallatticed
8 months ago

dark academia isn’t just for the humanities: i bring you STEM academia.

observatories. stargazing. biographies of scientists. filling the board end to end with equations. hand-drawn anatomical diagrams. the hazy euphoria after finally finishing an assignment. oppenheimer & frankenstein. the uniformity of a circuit board; the chaos of a programming window. ibm’s a boy and his atom. event horizon telescope’s black hole photo. the wonder of studying anatomy and knowing that’s happening within you. sketching organic compounds that may as well be sigils. studying latin for medical terminology. doing problem sets to classical music.

crystallatticed
8 months ago

Katherine Johnson: The Mathematician Who Launched Astronauts into Space and Women into STEM 🚀👩‍🚀

Katherine Johnson: The Mathematician Who Launched Astronauts Into Space And Women Into STEM 🚀👩‍🚀

In the vast expanse of the cosmos, where men first dreamed of reaching the stars, Katherine Johnson calculated the path that would get them there. This story isn't just about trajectories and orbits; it's about a woman whose brilliance in mathematics helped break the barriers of space and gender.

Katherine Johnson: The Mathematician Who Launched Astronauts Into Space And Women Into STEM 🚀👩‍🚀

Johnson's journey began in White Sulphur Springs, West Virginia, where her curiosity and intelligence shone from an early age. Despite encountering segregation and sexism, she charted a course that would lead her to NASA, where her skills became indispensable to the success of the U.S. space program. Her calculations were critical to the success of the Mercury missions, including John Glenn's pioneering orbital flight, for which he specifically requested Johnson verify the computer's numbers. "If she says they're good," Glenn said, "then I'm ready to go."

Katherine Johnson: The Mathematician Who Launched Astronauts Into Space And Women Into STEM 🚀👩‍🚀

But Johnson's contributions went beyond Mercury. She also played a role in the Apollo missions, including the first lunar landing, and her work on orbital mechanics laid the groundwork for the Space Shuttle program and plans for a Mars mission.

Katherine Johnson: The Mathematician Who Launched Astronauts Into Space And Women Into STEM 🚀👩‍🚀

Her legacy is a beacon for women and people of color in STEM, symbolizing the power of intelligence and perseverance to overcome societal constraints. Johnson's story teaches us that the path to the stars is paved with determination, hard work, and an unwavering belief in one's own abilities.

Katherine Johnson: The Mathematician Who Launched Astronauts Into Space And Women Into STEM 🚀👩‍🚀

Katherine Johnson's calculations helped lead humanity to the moon, but her impact extends far beyond the numbers. She charted a course for future generations of women in STEM, proving that the sky is not the limit—it's just the beginning. As we look up at the stars, we remember her legacy, not just as a mathematician, but as a trailblazer who launched us into a new era of exploration and equality.

crystallatticed
8 months ago

girl math this. girl math that. put some RESPECT on their names

Girl Math This. Girl Math That. Put Some RESPECT On Their Names
Girl Math This. Girl Math That. Put Some RESPECT On Their Names
Girl Math This. Girl Math That. Put Some RESPECT On Their Names
Girl Math This. Girl Math That. Put Some RESPECT On Their Names

(pictured: Emmy Noether; Sof'ja Vasil'evna Kovalevskaja; Katherine Johnson; Maryam Mirzakhani)

crystallatticed
8 months ago
I Look At This One Uh From Time To Time -

I look at this one uh from time to time -

crystallatticed
8 months ago
LaRue Burbank instructs her Data Systems and Analysis colleagues on the use of a computer.  She sits at a desk, pointing at a monitor. Her colleagues, two men, look over her right shoulder. Credit: NASA

LaRue Burbank, mathematician and computer, is just one of the many women who were instrumental to NASA missions.

4 Little Known Women Who Made Huge Contributions to NASA

Women have always played a significant role at NASA and its predecessor NACA, although for much of the agency’s history, they received neither the praise nor recognition that their contributions deserved. To celebrate Women’s History Month – and properly highlight some of the little-known women-led accomplishments of NASA’s early history – our archivists gathered the stories of four women whose work was critical to NASA’s success and paved the way for future generations.

LaRue Burbank: One of the Women Who Helped Land a Man on the Moon

LaRue Burbank was a trailblazing mathematician at NASA. Hired in 1954 at Langley Memorial Aeronautical Laboratory (now NASA’s Langley Research Center), she, like many other young women at NACA, the predecessor to NASA, had a bachelor's degree in mathematics. But unlike most, she also had a physics degree. For the next four years, she worked as a "human computer," conducting complex data analyses for engineers using calculators, slide rules, and other instruments. After NASA's founding, she continued this vital work for Project Mercury.

In 1962, she transferred to the newly established Manned Spacecraft Center (now NASA’s Johnson Space Center) in Houston, becoming one of the few female professionals and managers there.  Her expertise in electronics engineering led her to develop critical display systems used by flight controllers in Mission Control to monitor spacecraft during missions. Her work on the Apollo missions was vital to achieving President Kennedy's goal of landing a man on the Moon.

Eilene Galloway: How NASA became… NASA

Eilene Galloway in her home in Washington  on August 7, 2000. Photo from the collection of Herstory Interviews (1999-2002). Eilene Galloway sits in a cream-colored chair before a fireplace and bookshelf. Wearing a blue dress and suit jacket she looks towards the camera. In front of her on a desk sit multiple pieces of space legislation. Credit: NASA

Eilene Galloway wasn't a NASA employee, but she played a huge role in its very creation. In 1957, after the Soviet Union launched Sputnik, Senator Richard Russell Jr. called on Galloway, an expert on the Atomic Energy Act, to write a report on the U.S. response to the space race. Initially, legislators aimed to essentially re-write the Atomic Energy Act to handle the U.S. space goals. However, Galloway argued that the existing military framework wouldn't suffice – a new agency was needed to oversee both military and civilian aspects of space exploration. This included not just defense, but also meteorology, communications, and international cooperation.

Her work on the National Aeronautics and Space Act ensured NASA had the power to accomplish all these goals, without limitations from the Department of Defense or restrictions on international agreements. Galloway is even to thank for the name "National Aeronautics and Space Administration", as initially NASA was to be called “National Aeronautics and Space Agency” which was deemed to not carry enough weight and status for the wide-ranging role that NASA was to fill.

Barbara Scott: The “Star Trek Nerd” Who Led Our Understanding of the Stars

Barbara Scott (left) helps to plant a Moon Tree, a tree grown from a seed flown around the Moon, at the Goddard Visitor Center as William Mecca (center) and Dr. Robert Cooper (right) look on, 1977. This desaturated image features Barbara Scott in a professional dress and heels shoveling dirt around a sapling. Behind Scott, a small crowd of young women look on. In the far distance a line of trees blends with the horizon. Mecca wears a white lab coat; Cooper wears a suit jacket and dress pants. Credit: NASA

A self-described "Star Trek nerd," Barbara Scott's passion for space wasn't steered toward engineering by her guidance counselor. But that didn't stop her!  Fueled by her love of math and computer science, she landed at Goddard Spaceflight Center in 1977.  One of the first women working on flight software, Barbara's coding skills became instrumental on missions like the International Ultraviolet Explorer (IUE) and the Thermal Canister Experiment on the Space Shuttle's STS-3.  For the final decade of her impressive career, Scott managed the flight software for the iconic Hubble Space Telescope, a testament to her dedication to space exploration.

Dr. Claire Parkinson: An Early Pioneer in Climate Science Whose Work is Still Saving Lives

Dr. Claire Parkinson, 1999, posing with a sled dog at the North Pole during an expedition with NASA to Resolute Bay. Parkinson smiles, wears a large red winter coat with navy blue pants and pets the fluffy, majestic, and goodest sled dog sitting before her. In the background, other sled dogs are seen standing and sitting, and there is a single orange and navy-blue tent assembled in the background. The entirely of the background is dominated by the white snowy tundra of the North Pole. Credit: NASA

Dr. Claire Parkinson's love of math blossomed into a passion for climate science. Inspired by the Moon landing, and the fight for civil rights, she pursued a graduate degree in climatology.  In 1978, her talents landed her at Goddard, where she continued her research on sea ice modeling. But Parkinson's impact goes beyond theory.  She began analyzing satellite data, leading to a groundbreaking discovery: a decline in Arctic sea ice coverage between 1973 and 1987. This critical finding caught the attention of Senator Al Gore, highlighting the urgency of climate change.

Parkinson's leadership extended beyond research.  As Project Scientist for the Aqua satellite, she championed making its data freely available. This real-time information has benefitted countless projects, from wildfire management to weather forecasting, even aiding in monitoring the COVID-19 pandemic. Parkinson's dedication to understanding sea ice patterns and the impact of climate change continues to be a valuable resource for our planet.

Make sure to follow us on Tumblr for your regular dose of space! 

crystallatticed
8 months ago
Engineer Karen Leadlay In A General Dynamics Computer Lab, 1964.

Engineer Karen Leadlay in a General Dynamics computer lab, 1964.

crystallatticed
8 months ago
I'm Doing It Gang, I've Spent Stupider Gardening Money Before Like When I Dropped $300 On Shade Loving

I'm doing it gang, I've spent stupider gardening money before like when I dropped $300 on shade loving perennial bulbs only to learn they were also plants that rotted with wet feet and all immediately died in my swampy gumbo soil

I'm buying two firefly petunias. I've never grown petunias much because where I live they're a winter annual but fuck it I'll grow them as an indoor plant I certainly have the sun to do it.

They're supposed to ship to me in April, I'll report back on if they immidiately die or this is the coolest thing I own. My biochemical engineering design project was using a similar chemical pathway to modify bacteria to glow in the presence of specific toxins so I absolutely need glowing petunias in my window box

crystallatticed
8 months ago
Team calls for research on potential nanoplastic, Parkinson's link
Futurity
"The emergence of micro and nanoplastics in the environment might represent a new toxin challenge with respect to Parkinson's disease risk a

As reported in the journal Science Advances, the findings create a foundation for a new area of investigation, fueled by the timely impact of environmental factors on human biology. “Parkinson’s disease has been called the fastest growing neurological disorder in the world,” says principal investigator Andrew West, professor in the pharmacology and cancer biology department at Duke University School of Medicine. “Numerous lines of data suggest environmental factors might play a prominent role in Parkinson’s disease, but such factors have for the most part not been identified.” Improperly disposed plastics have been shown to break into very small pieces and accumulate in water and food supplies, and were found in the blood of most adults in a recent study. “Our study suggests that the emergence of micro and nanoplastics in the environment might represent a new toxin challenge with respect to Parkinson’s disease risk and progression,” West says. “This is especially concerning given the predicted increase in concentrations of these contaminants in our water and food supplies.”

Continue Reading.

crystallatticed
8 months ago

How Does The Drug Got Excreted / Eliminated From The Body?

How Does The Drug Got Excreted / Eliminated From The Body?

Drug excretion is an important process in pharmacology, encompassing the elimination of pharmaceutical substances from the body. While the ultimate elimination of all drugs is inevitable, the specific pathways involved can vary significantly. Some drugs undergo extensive metabolic transformations before being excreted, while others are expelled from the body in their original form.

The kidneys play a central role in excreting water-soluble substances, effectively filtering them from the bloodstream. Meanwhile, the biliary system handles drugs that remain unabsorbed from the gastrointestinal tract, providing an alternative route for elimination. Although excretion through auxiliary channels such as the intestines, saliva, sweat, breast milk, and lungs is typically minimal, certain volatile anesthetics and residual drug traces in breast milk can have notable impacts, particularly on vulnerable populations such as infants.

Renal excretion constitutes a significant portion of drug elimination, accounting for approximately 20% of the plasma that is filtered through the glomeruli. While most water and electrolytes are reabsorbed back into circulation, polar compounds like drug metabolites are excreted predominantly in urine. However, it’s important to note that renal excretion tends to decrease with age, necessitating careful dosage adjustments for elderly patients to mitigate potential adverse effects.

Numerous factors influence the process of renal excretion, including the extent of protein binding, the degree of drug ionization affecting reabsorption rates, fluctuations in urine pH that can alter excretion dynamics, and the impact of metabolic inhibitors on tubular secretion mechanisms.

Biliary elimination, on the other hand, occurs when drugs traverse the biliary epithelium via active transport mechanisms. However, this process is not without limitations, as transporter saturation can impose constraints on drug excretion rates. Typically, larger molecules containing polar and lipophilic groups are excreted through bile, while smaller molecules tend to favor renal elimination pathways.

In addition to renal and biliary routes, drugs may also be eliminated to varying extents through auxiliary pathways such as saliva, tears, feces, sweat, and exhalation. While the quantities eliminated through these routes are generally minimal, drug excretion in breast milk can pose significant concerns for lactating mothers, potentially exposing nursing infants to pharmacological agents.

Understanding the pharmacokinetic parameters governing drug excretion is paramount for optimizing therapeutic regimens and minimizing the risk of adverse effects. Key parameters include the rate of elimination, clearance, elimination rate constant, and biologic half-life for drugs undergoing first-order elimination kinetics.

In conclusion, drug excretion represents a broad process influenced by a myriad of factors, necessitating comprehensive consideration to ensure the safe and efficacious use of pharmacotherapy.

For medical students navigating the complexities of their studies, Expert Academic Assignment Help serves as a beacon of professionalism and expertise. With a steadfast dedication to excellence and competency, our team provides invaluable support and guidance tailored to your academic needs. Do not hesitate to reach out to us for assistance on your academic journey, email: expertassignment46@gmail.com 

Your excellence our pride.

crystallatticed
8 months ago
First page of an old book, written in Latin in Gothic letters. Big letters say "Concordie apothedariorus Barchiñ medicinis cõpositis Liber feliciter incipit." Below, there's a miniature woodcut print showing a man wearing 1500s clothing sitting at a desk writing and looking at an open book next to him.
Page of the same book, in Gothic letters it says "Cosma et Damiane" and there's a woodcut print of a man sick in bed surrounded by other men.
Book page all full of text printed in Gothic letters in Latin. At the bottom of the page, there's a woodcut print of two angels holding up Barcelona's shield. The page's margins, outside the text, are decorated with vegetal motifs.
Book page titled "Recipe", with the letter R as an illuminated letter. The text is printed in Latin in Gothic letters and shows a list of ingredients, with drawing of plants and saints on the margins.
Book page with a lot of text printed in Latin in Gothic letters. It includes a list and an explanation on how to make the recipe.

This is the Concòrdies, Europe's second oldest pharmacopoeia and the first of its kind. It was printed in 1511 in Barcelona, Catalonia. The first European pharmacopoeia was printed in Florence (modern-day Italy) in 1498 after a larger amount in Islamic countries, but both have some important differences.

A pharmacopoeia is a book that contains the recipes for making medicines, to be used as a reference guide by the apothecaries who made the remedies. The apothecaries were the chemists who made the drugs, specialists in medicinal herbs, minerals, animal products and food.

On August 29th 1510, the king Ferdinand of Catalonia-Aragon gave Barcelona's Apothecaries Association the royal privilege of standardizing the recipes used for making drugs. Before this, doctors diagnosed their patients and told them what drugs to buy, but each apothecary made it in their way, which could have different amounts of each ingredient or different preparations. This could lead to results that weren't as good as expected.

You might have noticed that the book is titled "Concordie apothecarioru[m] Barchin[one] i[n] medicinis co[m]positis liber feliciter incipit" (more or less "Agreement of Barcelona's apothecaries on the compound medicines" in Latin), often shortened to "les Concòrdies" ("the Agreements" in Catalan). It's an "agreement" because the apothecaries came together to write the most effective recipes, which they then presented to the Barcelona Medicine Doctors' Association. Then, the doctors could object or not, and from the agreement between both experts resulted this book.

This is the first pharmacopoeia that was made by the apothecaries' idea, not following orders of a government, and the first pharmacopoeia written for and by the apothecaries (the book written in Florence was made by doctors to tell apothecaries what they wanted them to make). Thanks to their apothecaries' work, Barcelona's inhabitants were the first people in the Iberian peninsula to access homologated medicine. Soon, this book's rules were expanded to all of Catalonia.

The only remaining original copy from the 1511 edition is kept in the Museum of Catalan Pharmacology which belongs to the University of Barcelona. The whole book has been digitalized and is completely uploaded online: here's the link.

crystallatticed
8 months ago

Pharmacology Unveiled: How Medications Work on a Molecular Level"

Explore the science of pharmacology and delve into the mechanisms of action of commonly prescribed medications, shedding light on how they interact with the body's systems.

In the multifaceted domain of pharmacology, an intricate symphony of molecular interactions orchestrates the therapeutic effects of medications. A profound comprehension of the molecular underpinnings of pharmacological actions is indispensable for healthcare professionals, pharmaceutical scientists, and researchers. In this discourse, we embark on a comprehensive exploration of pharmacodynamics, elucidating the profound intricacies of how medications function at the molecular level.

Pharmacodynamics: A Multilayered Discipline

Pharmacodynamics constitutes the extensive scrutiny of the manner in which drugs interlace with specific molecular targets, often referred to as receptors or enzymes, within the human organism. Medications are meticulously designed to effectuate alterations in biochemical pathways, receptor kinetics, or enzymatic processes, aiming to modulate physiological phenomena to alleviate symptoms or remediate pathological states.

Receptor-Mediated Pharmacological Actions

A pivotal facet of pharmacodynamics lies in the receptor-mediated actions of medications. Receptors are intricate protein entities, frequently situated on the extracellular or intracellular domains of cells, that play a pivotal role in cellular communication and homeostasis. When a medication interfaces with a receptor, it initiates a cascade of molecular events, which, contingent upon the context, may potentiate or impede the cellular response.

Agonists and Antagonists: Puppets of Molecular Dance

In the intricate theater of pharmacodynamics, medications assume roles as either agonists or antagonists. Agonists aptly mimic the endogenous ligands or signaling molecules, seamlessly integrating into the receptor's binding pocket. This engagement sets forth a conformational alteration in the receptor, instigating cellular events replicating or augmenting the physiological response. Conversely, antagonists function as molecular antagonists, obstructing the receptor and forestalling the binding of endogenous signaling molecules. Consequently, the physiological response is negated or attenuated.

Enzymatic Interference: Orchestrating Biochemical Concertos

Certain medications orchestrate their therapeutic influence through the intricate domain of enzyme inhibition. Enzymes are the catalytic workhorses governing biochemical transformations in biological systems. Medications that selectively inhibit or modulate these enzymes effectively regulate the pace or character of these metabolic reactions, rendering them invaluable in conditions characterized by aberrant enzyme function.

Ion Channel Choreography: Modulating Electrophysiological Ballets

A notable mechanism of pharmacological action entails the modulation of ion channels. These proteinaceous conduits, reposing within cellular membranes, govern the flux of ions across these barriers. Medications designed to engage with ion channels effectively influence the electrochemical signaling within cells. The modulation of ion channels is instrumental in conditions such as arrhythmias, epilepsy, and neuropathic pain.

Pharmacogenetics: Personalizing Medication Regimens

The burgeoning realm of pharmacogenetics delves into the impact of an individual's genetic repertoire on their medication response. Genetic polymorphisms can significantly influence drug metabolism, receptor sensitivities, and pharmacological efficacy. Tailoring medication regimens to align with an individual's genetic makeup represents a burgeoning paradigm in personalized medicine.

Pharmacology unfolds as an intricate tapestry of molecular engagements and multifarious mechanisms. Medications, hewn with precision, are intended to engage with specific molecular entities, be it receptors, enzymes, or ion channels, aiming to modulate intricate biochemical processes to achieve therapeutic ends.

References

Rang, H. P., Dale, M. M., Ritter, J. M., & Flower, R. J. (2015). Rang & Dale's Pharmacology. Elsevier.

Katzung, B. G., & Trevor, A. J. (2021). Basic & Clinical Pharmacology. McGraw-Hill Education

Brunton, L. L., Knollmann, B. C., & Hilal-Dandan, R. (2020). Goodman & Gilman's: The Pharmacological Basis of Therapeutics. McGraw-Hill Education.

Pharmacology Unveiled: How Medications Work On A Molecular Level"
crystallatticed
8 months ago
Ebola: Scientists reveal a new way it replicates
phys.org
Scientists in Canada and the U.S. have discovered a new way in which Ebola—an often deadly virus affecting people mostly in sub-Saharan Afri

Scientists in Canada and the U.S. have discovered a new way in which Ebola—an often deadly virus affecting people mostly in sub-Saharan Africa—reproduces in the body. By shedding light on how the virus interacts with a human protein called ubiquitin, the researchers have also identified a potential target for new drugs to prevent the disease.

Continue Reading.

crystallatticed
8 months ago
Pharmacist’s Display

pharmacist’s display

crystallatticed
8 months ago

Illiterate pharmacist who can only tell medications apart by crushing them up and tasting the molecules

crystallatticed
8 months ago
How insects can tell different sugars apart
Futurity
The discovery of how insects can tell different sugars apart could one day help humans mimic that ability, researchers say.

Whereas humans have one receptor on their tongues that can detect all sorts of sweet things, from real sugar to artificial sweeteners like aspartame, insects have many receptors that each detect specific types of sugars. The new research reveals one way insect receptors are able to be so selective. The new discovery will help us understand how animals decipher the chemical world and how we might mimic that ability in the future, the researchers say.

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crystallatticed
8 months ago
Milky Way Over Aragi Island Rice Terraces.

Milky way over Aragi island rice terraces.

Wakayama, Japan.

crystallatticed
8 months ago
Scientists Find 3,600 Food Packaging Chemicals in Human Bodies
ScienceAlert
Some are considered to be of "high concern".

More than 3,600 chemicals used in food packaging or preparation have been detected in human bodies, some of which are hazardous to health, while little is known about others, a study published on Tuesday said. Around 100 of these chemicals are considered to be of "high concern" to human health, said lead study author Birgit Geueke from the Food Packaging Forum Foundation, a Zurich-based NGO. Some of these chemicals are relatively well-studied and have already been found in human bodies, such as PFAS and bisphenol A – both of which are the target of bans.

Continue Reading.

crystallatticed
8 months ago
Manganese nanoparticles can more than double availability of world's potable water, say scientists
phys.org
Manganese ferrite nanoparticles could lead to a substantial surge in the availability of drinking water globally when used to modify the fil

Manganese ferrite nanoparticles could lead to a substantial surge in the availability of drinking water globally when used to modify the filtering sheets currently used in water treatment plants, according to scientists. "Our study records some extraordinary results. The top-performing membrane, containing 2 wt.% composite material, achieved a water flux of 351.4 LMH, which is 2.6-fold higher than the pristine PES membranes," said study co-author Dr. Ismail Almanassra, a research associate at the University of Sharjah's Institute for Science and Engineering. PES or polyethersulfone membranes are vital for water treatment plants since they function as barriers allowing potable water to pass and preventing unwanted substances getting through them. They filter salts, impurities, and other unwanted particles from water.

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crystallatticed
8 months ago
Vermont 🇺🇸

Vermont 🇺🇸

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