Brain’s Immune Cells Linked To Alzheimer’s, Parkinson’s, Schizophrenia

Brain’s Immune Cells Linked to Alzheimer’s, Parkinson’s, Schizophrenia

Researchers at UC San Diego School of Medicine and the Salk Institute have, for the first time, characterized the molecular markers that make the brain’s front lines of immune defense — cells called microglia — unique. In the process, they discovered further evidence that microglia may play roles in a variety of neurodegenerative and psychiatric illnesses, including Alzheimer’s, Parkinson’s and Huntington’s diseases as well as schizophrenia, autism and depression.

Genes that have previously been linked to neurological diseases are turned on at higher levels in microglia compared to other brain cells, the team reported in Science on May 24, 2017. While the link between microglia and a number of disorders has been explored in the past, the new study offers a molecular basis for this connection.

Brain’s Immune Cells Linked To Alzheimer’s, Parkinson’s, Schizophrenia

Rat microglia are shown here in green, neurons in red

“These studies represent the first systematic effort to molecularly decode microglia,” says Christopher Glass, PhD, professor at UC San Diego School of Medicine. “Our findings provide the foundations for understanding the underlying mechanisms that determine beneficial or pathological functions of these cells.” Glass led the study with Salk’s Rusty Gage, PhD.

More work is needed to understand exactly how microglia may be altered in people with diseases, but the new molecular profile of microglia offers a way for researchers to begin trying to better culture the cells, or coax stem cells to develop into microglia for future studies.

For more about this study, read the paper and press release.

More Posts from Karlfelersii and Others

7 years ago

15+ Things We Wish People Understood About Anxiety

15+ Things We Wish People Understood About Anxiety

It is utterly exhausting living in a near constant state of fight or flight for so long.

Continue Reading 

7 years ago

Brain patterns underlying mothers’ responses to infant cries

Infant cries activate specific brain regions related to movement and speech, according to a National Institutes of Health study of mothers in 11 countries. The findings, led by researchers at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), identify behaviors and underlying brain activities that are consistent among mothers from different cultures. Understanding these reactions may help in identifying and treating caregivers at risk for child maltreatment and other problematic behaviors.

Brain Patterns Underlying Mothers’ Responses To Infant Cries

The study team conducted a series of behavioral and brain imaging studies using functional magnetic resonance imaging (fMRI). In a group of 684 new mothers in Argentina, Belgium, Brazil, Cameroon, France, Israel, Italy, Japan, Kenya, South Korea and the United States, researchers observed and recorded one hour of interaction between the mothers and their 5-month-old babies at home. The team analyzed whether mothers responded to their baby’s cries by showing affection, distracting, nurturing (like feeding or diapering), picking up and holding, or talking. Regardless of which country they came from, mothers were likely to pick up and hold or talk to their crying infant.

Through fMRI studies of other groups of women, the team found that infant cries activated similar brain regions in new and experienced mothers: the supplementary motor area, which is associated with the intention to move and speak; the inferior frontal regions, which are involved in the production of speech; and the superior temporal regions that are linked to sound processing.

Overall, the findings suggest that mothers’ responses to infant cries are hard-wired and generalizable across cultures. The study also builds upon earlier work showing that women’s and men’s brains respond differently to infant cries.

7 years ago
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6 years ago
Don’t Forget To Order You Psychology Department Sweatshirt!! Now Accepting VENMO!!! Https://www.instagram.com/p/Bq0lFpdFdth/?utm_source=ig_tumblr_share&igshid=qzde5ezgl6e1

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6 years ago
Researchers Discover Key Link Between Mitochondria And Cocaine Addiction

Researchers Discover Key Link Between Mitochondria and Cocaine Addiction

For years, scientists have known that mitochondria—the power source of cells—play a role in brain disorders such as depression, bipolar disorder, anxiety and stress responses. But recently scientists at the University of Maryland School of Medicine (UMSOM) have identified significant mitochondrial changes in brain cells that take place in cocaine addiction, and they have been able to block them.

In mice exposed repeatedly to cocaine, UMSOM researchers were able to identify an increase in a molecule that plays a role in mitochondria division (or fission) in a reward region of the brain. Researchers were able to block this change by using a special chemical, Mdivi-1. The researchers also blocked responses to cocaine by genetically manipulating the fission molecule within the mitochondria of brain cells, according to research published in Neuron.

“We are actually showing a new role for mitochondria in cocaine-induced behavior, and it’s important for us to further investigate that role,” said Mary Kay Lobo, PhD, Associate Professor of Anatomy and Neurobiology.

The researchers initially studied the mitochondria in cocaine-exposed mice and determined that mitochondria fission increased in the major reward region of the brain. To confirm this same change in humans, researchers were able to identify similar changes in the mitochondrial fission molecule in tissue collected from post mortem individuals who were cocaine dependents.

Dr. Lobo said that this latest research could help UMSOM researchers better understand changes in brain cells and mitochondria from other addictive disorders. “We are interested to see if there are mitochondrial changes when animals are taking opiates. That is definitely a future direction for the lab,” she said.

8 years ago
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.
Superstitions Around The World.

Superstitions around the world.

Anyone interested in a psychology article about superstitions and why some people believe in them? Follow me and I will make a post @mypsychology

7 years ago

Is Witchcraft a Placebo?

What is the “placebo effect” -  a beneficial effect, produced by a placebo drug or treatment, that cannot be attributed to the properties of the placebo itself, and must therefore be due to the patient’s belief in that treatment

One of the hardest aspects of witchcraft is proving it actually works. When it comes to spell jars, sigils, and other energy type work the only proof we have of its abilities to actually do anything is our own experiences.

Think of it this way:

You create a spell jar to banish negative energy from your home. You’ve been having this feeling in your gut that something just isn’t right. When you come home you feel some sort of bad mojo around you.

So you put together a spell jar. You collect all your ingredients and you perform your spell. Everything went just as planned and you have your jar all finished. You decide to place it on your altar or maybe you choose to bury it in your yard, or place it somewhere hidden like a closet or dresser..

You start to feel a lightness surrounding you (like that heavy bad feeling is gone or at the very least, slowing dissipating). ~ it’s working ~ the spell is actually working…. or is it?

You’ve been told that this will banish the negative energy from your home and you believe it. So did a jar full of herbs, objects and whatever else you used actually banish the negative energy? Or did it work because you believed it would? 

We’ve argued to a point of exhaustion about intent in witchcraft. “All you need is intent, everything else is just extra shit.” You ever wonder why witches tell you this? It’s because they have some awareness that all you need to do is believe it works and it’ll work. 

I’m not one of these witches lol. I’m into science and hard facts. Which is probably why my craft mostly centers around herbalism (and the medicinal properties of herbs) but I do still use crystals, candles and I’m a tarot reader but that doesn’t mean I’m not self-aware. I understand that my craft will be questioned and what kind of witch would I be if I didn’t also question my own craft and how it works. 

Of course I’m not saying magick isn’t real or that witchcraft is just made up bologna. I am a witch afterall lol. What I am saying is that witchcraft and the placebo effect are very similar.

There have been medical studies where they’ve found that more than 30% of those given a placebo reported the same results as those given the actual drug. This begs the question; are the active ingredients (or properties) in the drugs actually doing anything? or is the power of suggestion strong enough to mimic the results of the drug in question?

Thoughts?

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