(via Https://www.youtube.com/watch?v=I-Z59JVF2jw)

THC found to remove plaque-forming Alzheimer’s proteins, reduce inflammation, and protect nerve cells

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.

While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer’s disease and could provide clues to developing novel therapeutics for the disorder.

“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.

READ MORE ON SALK INSTITUTE FOR BIOLOGICAL STUDIES

Ref: Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. NPJ Aging and Mechanisms of Disease (23 June 2016) | DOI: 10.1038/npjamd.2016.12 | PDF (Open Access)

ABSTRACT

The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood. We use a proteotoxicity model based upon the inducible expression of Aβ in a human central nervous system nerve cell line to characterize a distinct form of nerve cell death caused by intracellular Aβ. It is shown that intracellular Aβ initiates a toxic inflammatory response leading to the cell’s demise. Aβ induces the expression of multiple proinflammatory genes and an increase in both arachidonic acid and eicosanoids, including prostaglandins that are neuroprotective and leukotrienes that potentiate death. Cannabinoids such as tetrahydrocannabinol stimulate the removal of intraneuronal Aβ, block the inflammatory response, and are protective. Altogether these data show that there is a complex and likely autocatalytic inflammatory response within nerve cells caused by the accumulation of intracellular Aβ, and that this early form of proteotoxicity can be blocked by the activation of cannabinoid receptors.

❝ ‘Henry VII’s devout and rather awesome mother’, was the description the historian Neville Williams offered of Margaret Beaufort in his 1973 biography of the King. Both adjectives in this statement are true, but neither do full justice to the woman who forms the subject of this book. William’s assessment does, however, accurately summarize the way in which Margaret has often been portrayed: a religious fanatic who was obsessively ambitious on her son’s behalf and dominated his court, an image compounded by the effigy upon her tomb as well as the surviving portraits, which show her wearing widow’s weeds and a barbed wimple, on her knees in prayer. This is an image often conjured up when the name Margaret Beaufort is mentioned. Yet it is two-dimensional as the paintings themselves, frequently used as a convenient short-hand when relating the tales of the period. Margaret’s own story and her true character as a living, breathing woman are a far cry from such flat representations.Nicola Tallis, Uncrowned Queen: The Fateful Life of Margaret Beaufort, Tudor Matriarch.

هذا الحوت يسمى الحوت الرمادي الصلب الذي يبلغ وزنه 40 طن، في الفيديو يظهر لطافته.

This whale is called the solid gray whale, which weighs 40 tons, in the video it shows kindness.

So You Want to Transition? - 10 Tips to Keep in Mind

1.      Be Patient – Don’t set a time to become fully natural. Hair grows on average ½” per month. Look at your hair about 4-6 months into your transition to see where you are. Use this amount of growth as a gage to calculate your growth rate. This should help you determine how much longer it will take you to reach your desired “Big Chop*” length.  

*Big Chop – Cutting off all of the chemically processed hair

2.       Trim Regularly – Trim your hair every 4-6 weeks to prevent breakage. Don’t retain dead/split ends for lengths sake. This will only cause any split ends to split further up the shaft, causing unnecessary breakage

3.       Find your Go To Style – Find your go to transitioning style. Trying to blend 2 very different textures can be quite difficult and frustrating, especially if it doesn’t blend like you may want it to. Bantu knot outs and twist outs (add a perm rod or straw to curl the ends) are a great go to styles to blend the two textures of your hair. Braids and weaves are a great option as well, but make sure your braids aren’t too tight that they pull on your edges. Also, let your hair breathe between each weave or set of braids. Try different styles that you can mix and match for different occasions.

4.    Cleanse. Condition. Moisturize. –

Cleanse – When cleansing/shampooing your hair be sure to use a sulfate-free shampoo. When shampooing your hair concentrate on your scalp, cleanse your scalp every 2 day to every 2 weeks. This will all depend on your scalp. Don’t over cleanse and strip your hair of its natural oils. Also, don’t under cleanse and have buildup that can cause dandruff.  I suggest starting with washing every week and seeing how your scalp reacts to it. If it’s too much, go longer between washes. If it’s too little, go shorter between washes until you find the right balance for you. Also, to stretch between shampoos, as washing your hair too much with even a sulfate-free shampoo can be drying, try co-washing*.

*Co-wash – to wash your hair with conditioner

Condition – Make sure to deep condition your hair at least once a week. Find a DC that works for you that will really moisturize your hair. I would say if you are not shampooing, then use a deep conditioner (DC) after you co-wash. For co-washing conditioners use one a cheap conditioner with lots of slip. I use Suave Naturals Apple Conditioner. It’s $1 at Walgreens. Be sure to find one that is inexpensive as you will be using a lot of it.

Moisturize –Learn this early, as this step will be key in your natural hair journey. Up until recently, I have always had a struggle with keeping my hair moisturized. Lately, what’s working for me is using products without silicones. Silicones are ingredients that stay on the hair strand and can block moisture in the air from flowing in and out of the hair naturally. Water will always be your best friend in the constant moisture battle. Always look for products where the first ingredient is water, this will help you keep your hair moisturized in between shampoos and co-washes. Also, try the LOC method (Liquid, usually water, Oil and Cream). I’m currently trying this method and it is working for me. After you shampoo or co-wash, with your hair soaking wet, seal the water with the oil of your choice. “The coarser your hair the thicker the oil should be.” Remember to mind the seasons, as winter can be more drying. Try different oils to see which one works for your hair. Then apply a cream based product over the oil. I’m currently using Camille Rose Naturals Moisture Milk. I also apply this when my hair is completely dry between washes.

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