Lmao What Did Ariana Do That Means She Needs To Get Booed At Manchester?

Forgot I made these quick refs once!! It’s not that you should feel obligated to portray every part of an animal correctly, but in some cases these are very unique, interesting features that very few artists are ever utilizing creatively!

okay, here’s a really cool concept:

You’re ridiculously confident. Confident enough to not give a single eff about what they’re thinking when you go do the crazy things that you do.

You’re brave. Brave enough to stay true to your deepest values and desires where most follow the crowd blindly.

You’re insane, or at least that’s what they call you. Insane to want big dreams and then chase them with all of your might when others are still stuck in cages of self-doubt and hesitance.

You’re kind. Kind enough to portray your compassion and true humanity in a world where most are living fake, plastic lives and refuse to show just a little more kindness.

You’re beautiful. Always were and always will be. Your eyes sparkle with hope and positivity and your smile is angelic. When you laugh, it’s pure joy, and seeing you happy makes others happy as well.

You’re strong. Strong enough to get through all the difficulties and resistance you’re experiencing now and find faith and love on the other side.

You’re capable, wildly capable. Capable of your dreams and the desires that keep you awake at night, keep you alive. You truly deserve to make them a reality.

But most importantly, you’re free. Free now. Alive now. You have the freedom, the time and the responsibility to choose what kind of a person you want to be today when you go out into the world. So choose now. And choose to be the real you, not someone else that people have made you believe you are. Choose.

so I got into grad school today with my shitty 2.8 gpa and the moral of the story is reblog those good luck posts for the love of god

tag yourself: note takers edition

Takes digital notes: tries to keep up with notetaking but eventually falls behind after 5 lectures, drinks coffee only to stay awake, tries the aesthetic of drinking hot tea while taking notes but fails, wakes up early once in a century and thinks they’ve reached their peak, wants a better organisation system but is too tired, worries about studyspo for 2 mins before saying fuck it

Takes handwritten notes: have really nice handwriting but they don’t realise it themselves, headers!! are!! everything!!, have a love-hate relationship with taking notes, studying only when they feel like it, only writes key points as notes because everything else is too much, drifts off a lot while notetaking to daydream

Doesn’t take notes: wears hoodies like 90% of the time, tries really hard to take care of themselves but it’s hard™, hair in a bun because hairstyles?? too much work, yells “fuck the system” as they study more than anyone else, studies straight from books and Knows what to study, can’t study for more than 45 mins at a time, is productive nonetheless, kinda exhausted but still carrying on

Takes notes only in class: take! notes! in! class! save! your! time! fuckers!, in a constant state of chaos but they’ll never admit, have a great relationship with the professors, raises eyebrows at everything it’s a Brand, likes lunch dates a lot, hates people who talk during lectures, wants a vacation already

Is still rotating between handwriting and typed notes: “did we have any homework” at the beginning of every lecture, is really friendly but tired of everything, likes laughing at stupid jokes, hates studying but is still doing it anyway, Major Chaos™, everyone loves them but they don’t have a lot of close friends, will fight for their friends to death, the mood: they’re just being their ball of anxiety, let them live thnx

“If we break up, I want closure. None of this bitter high school mentality that usually follows after someone leaves. I want a long talk about what went wrong, why we couldn’t fix it, and how we’ll move on afterward. I want to know how I made you feel and what thought-process led you to the decision that you’re making. Because if I spent a fraction of my life devoted to loving you, you can’t expect me to let you go without any explanation as to why you’re going in the first place. If I love you, there will always be a piece of me that loves you. So let’s talk it through and forgive each other, neither of us are perfect and we’re both still learning how to love. And that’s okay, it is. But instead of seeing each other the next day and awkwardly pretending we weren’t ever anything at all, let’s forgive each other now and move on. Make peace.”

— Car thoughts #150

are you a pink lemonade gay or a vanilla coke gay? sword gay or axe gay? cats and dogs gay or snakes and lizards gay? string lights gay or neon lights gay?

The International Space Station: Apex of International Collaboration

It’s National Space Day! To mark the occasion, we’re reflecting on the International Space Station, which has been continuously occupied since Nov. 2, 2000. As our orbiting laboratory that enables us to conduct important science off our home planet, the ISS allows researchers from all over the world to put their talents to work on innovative experiments in the microgravity environment. An international partnership of space agencies provides and operates the elements of the ISS. The principals are the space agencies of the United States, Russia, Europe, Japan and Canada. Although each space station partner has distinct agency goals for station research, each partner shares a unified goal to extend the resulting knowledge for the betterment of humanity! Here are 5 fun facts about our about our out-of-this world floating laboratory:

1. The ISS is a unique scientific platform that has enabled more than 3,600 researchers in 106 countries and areas to conduct more than 2,500 experiments in microgravity through February 2018—and the research continues. 

2. Astronauts and cosmonauts have conducted more than 205 spacewalks (and counting!) for space station construction, maintenance and repair since December 1998.

3. The station’s orbital path takes it over 90 percent of the Earth’s population, with astronauts taking millions of images of the planet below. 

4. Six spaceships can be connected to the space station at once.

5. An international crew of at most six people live and work while traveling at a speed of five miles per second, orbiting Earth about every 90 minutes.

Currently, six humans are living and working on the International Space Station, which orbits 250 miles above our planet at 17,500mph. 

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com.

Antimicrobial Agents  - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

 Modes of action Interference with: 

cell wall synthesis 

protein synthesis 

nucleic acid synthesis 

plasma membrane integrity 

metabolic pathway 

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis 

The Beta-lactam Family 

The Glycopeptides 

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids.  Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams 

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis. 

Glycopeptides 

Polypeptide agents - basic structural elements amino acids 

Vancomycin: 

complexes with peptide portion of peptidoglycan’s precursor units 

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses:  serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve 

hearing loss (ototoxicity) 

“Red man/neck” syndrome - rash on face, neck, upper torso 

I’m so happy for you!