Three Muscle Fibers; The Middle Has A Defect Found In Some Neuromuscular Diseases

This week in “TBDMSCl crystals”

In this video, mixtures of inks (likely printer toners) and fluids move and swirl. Magnetic fields contort the ferrofluidic ink and make it dance, while less viscous fluids spread into their surroundings via finger-like protuberances. (Video credit and submission: Antoine Delach)

Silica nanoparticles could be used to repair damaged teeth

Researchers at the University of Birmingham have shown how the development of coated silica nanoparticles could be used in restorative treatment of sensitive teeth and preventing the onset of tooth decay.

The study, published in the Journal of Dentistry, shows how sub-micron silica particles can be prepared to deliver important compounds into damaged teeth through tubules in the dentine.

The tiny particles can be bound to compounds ranging from calcium tooth building materials to antimicrobials that prevent infection.

Professor Damien Walmsley, from the School of Dentistry at the University of Birmingham, explained, “The dentine of our teeth have numerous microscopic holes, which are the entrances to tubules that run through to the nerve. When your outer enamel is breached, the exposure of these tubules is really noticeable. If you drink something cold, you can feel the sensitivity in your teeth because these tubules run directly through to the nerve and the soft tissue of the tooth.”

“Our plan was to use target those same tubules with a multifunctional agent that can help repair and restore the tooth, while protecting it against further infection that could penetrate the pulp and cause irreversible damage.”

The aim of restorative agents is to increase the mineral content of both the enamel and dentine, with the particles acting like seeds for further growth that would close the tubules.

Previous attempts have used compounds of calcium fluoride, combinations of carbonate-hydroxypatite nanocrystals and bioactive glass, but all have seen limited success as they are liable to aggregate on delivery to the tubules. This prevents them from being able to enter the opening which is only 1 to 4 microns in width.

However, the Birmingham team turned to sub-micron silica particles that had been prepared with a surface coating to reduce the chance of aggregation.

When observed using high definition SEM (Scanning Electron Microsopy), the researchers saw promising signs that suggested that the aggregation obstacle had been overcome.

Professor Zoe Pikramenou, from the School of Chemistry at the University of Birmingham, said, “These silica particles are available in a range of sizes, from nanometre to sub-micron, without altering their porous nature. It is this that makes them an ideal container for calcium based compounds to restore the teeth, and antibacterial compounds to protect them. All we needed to do was find the right way of coating them to get them to their target.  We have found that different coatings does change the way that they interact with the tooth surface.”

“We tested a number of different options to see which would allow for the highest level particle penetration into the tubules, and identified a hydrophobic surface coating that provides real hope for the development of an effective agent.”

Our next steps are to optimise the coatings and then see how effective the particles are blocking the communication with the inside of the tooth.  The ultimate aim is to provide relief from the pain of sensitivity.

University of Birmingham

Nanotechnology World Association

Double, double toil and trouble;

Reaction stir and oil bubble.

Space Lettuce in the White House Kitchen Garden

While most people plant gardens on Earth, we’re working to cultivate one in space!

On April 5, the First Lady welcomed students from across the country as well as NASA Deputy Administrator Dava Newman and NASA astronaut Cady Coleman to the White House Kitchen Garden.

While there, they planted various produce, including the same variety of lettuce that will be sent to the International Space Station on the April 8 SpaceX cargo launch.

These seeds were prepared and packaged for both the First Lady’s garden, as well as the batch headed up to space station. “Outredgeous” Red Romaine Lettuce and “Tokyo bekana” Chinese Cabbage will soon be growing in both gardens!

Why do we grow plants in space?

Our Veggie plant growth system on the space station provides lighting and nutrient supply for a space garden. It supports a variety of plant species that can be cultivated for educational outreach, fresh food and even recreation for crew members on long-duration missions.

When crews travel farther into space, they will need a self-sustaining life support system, and that means growing their own food.

How do we grow plants in space? Here’s a resource for “Space Gardening 101”.

Want to see the space station seeds launch? You can watch Friday’s SpaceX cargo launch live online starting at 3:30 p.m. EDT, with launch scheduled for 4:43 p.m.

Make sure to follow us on Tumblr for your regular dose of space: http://nasa.tumblr.com

Also, while this is on my mind. In my master’s-level food toxicology class today we discussed various genetically modified crops and watched part of a documentary about them, and as someone with a food science degree I would like to be clear about the following:

The only health risk that has been shown to us throughout twenty plus years of having genetically modified crops as part of the food system is that there is a possibility of introducing proteins that could cause allergic reactions. New strains are required to be tested for this, of course, but that is a practical risk that needs to be closely monitored.

The objection to GM in general should be the patenting of genes and other legal matters; there are a number of crops that have been saved from blight and overall extinction via modification in the past two decades, and much like putting up inaccessibly expensive paywalls to scientific journals, patenting of genes within crops limits our ability within universities, small research companies, etc to make significant breakthroughs to further the scientific progress of humanity. 

Furthermore. People think of organic crops as the environmentally-friendly option. If you believe this, please pay attention to what I’m about to say. Current regulations dictate that to have a crop classified as organic the land on which the crop is grown has to have been pesticide-free for a significant amount of time. There is no interim label available to farmers. So what do they do? Do they use no pesticides and take the losses from disease and insects for a decade, waiting for a time in which they are allowed to reclassify their crops in such a way that they can sell them for more money?

Of course they don’t. It isn’t practical. You can say what you like about how the system is structured; I’d personally like to see an interim classification come into play. But what farmers actually do, and states like Montana are feeling the full effects of this–they clear-cut forests and plant their organic crops on entirely new land.

You want to tell me that clear-cutting forests is environmentally friendly? It’s not. Hell, for all that people make a big deal about saving the environment by limiting how much paper they use, paper production is done in a more sustainable manner (because the paper farms replant their trees in a regular cycle so as to not deplete their sources; they don’t just go out and cut down random trees). 

There are objections to be had in regards to GM crops on a legal basis. On a scientific one, there isn’t much. Call them frankenfoods all you want; look up what most commercially-sold produce truly looks like in the wild with no modification and you will learn very quickly that all foods have been modified in some way over the years through conventional breeding. We just think of that differently. 

Biotechnology is not the enemy. Pseudoscience tells us that this is the case. Pseudoscience also tells us that we should seek out natural supplements instead of medicine, and, well… that’s a rant for another day, but suffice to say it’s an even more dubious proposition.

Don’t buy into it.

Brine is your friend 

*gags then googles how to get rid of an emulsion*

Earth as seen from Saturn.

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‘BLOOD LAMP’ Mike Thompson, an artist based in Amsterdam, wanted to design a piece that forced people to think about the cost of the power they use. So he made a lamp lit with the user’s blood. His “Blood Lamp” glows thanks to a reaction with luminol, a molecule used in police forensics that gives off electric blue light when exposed to an iron-rich protein in blood called hemoglobin. Iron atoms catalyze the oxidation of luminol, creating a high-energy, unstable peroxide molecule that releases energy as blue light as it relaxes to its low-energy ground state. After the user adds blood and the reaction consumes all of the luminol, the light fades, and the lamp can never be used again.

Credit: Mike Thompson

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