Right Lateral Thoracic Wall Mass From A 10 Year-old, Female-spayed, Golden Retriever.  Approximately

Menstruation products* but yeah real safety would be making them free as they should be 🙃

There was a sensitive pragmatic question which needed to be answered, however. To put it bluntly: Was Arya going to be naked on camera? Many cast members have appeared nude on the show, though typically signed on when they were at least 18 years old (and often agreed to nudity as part of their deal). The 22-year-old Williams joined Thrones when she was 11 and has grown up in front of fans. Williams says the showrunners let her decide precisely how much to show. “David and Dan were like: ‘You can show as much or as little as you want,’” Williams says. “So I kept myself pretty private. I don’t think it’s important for Arya to flash. This beat isn’t really about that. And everybody else has already done it on the show, so…”

Still, when it came time to film the encounter, Williams had to be naked-ish on set, and that was a naturally a bit awkward. “In the beginning, everyone was really respectful,” she says. “No one wants to make you feel uncomfortable which kind of makes you feel more uncomfortable, because no one wants to look at anything that they shouldn’t look at which in turn makes you feel like you look awful because everyone is kind of like—” [Williams averts her eyes]. “You want people to act more normal.”

Continues Williams: “Then [the scene] was rushed. We were [directed by] David Nutter, who has a habit of speaking fast anyway. By the end we’re rushing to finish the scene and David is going, ‘Okay, you’re going to come in and do this and do that and, great, take your top off’ — and then walked off. And I’m like … ‘Okay. Let’s do it.”

Dempsie suggested the experience was strange for him too for given how long he’s known Williams, who’s about a decade younger than him. “It’s obviously slightly strange for me because I’ve known Maisie since she was 11, 12 years old,” says the 31-year-old actor. “At the same time, I don’t want to be patronizing toward Maisie — she’s a 20-year-old woman. So we just had a lot of fun with it.”

But Williams says what’s most important to her about Arya’s battle-eve night of romance wasn’t reading the scene or even filming it, but rather what this moment meant for her character. Year after year, Arya has been laser-focused on survival and training and revenge. Being with Gendry meant that, for one night at least, Arya had an experience that put her back in touch with her humanity.

“It was really interesting because it’s a very human relationship for Arya,” Williams says. “This is something she’s stayed away from, an emotion we’ve never really seen her engage with. David and Dan were like, ‘It’s the end of the world, what else would you have her do?’ This may be is a moment where Arya accepts death tomorrow, which she never does — ‘Not Today.’ So it was that moment where she says, ‘We’re probably going to die tomorrow, I want to know what this feels like before that happens.’ It’s interesting to see Arya be a bit more human, speak more normally about things people are scared of.” — Maisie Williams discusses Arya’s surprise Gendry scene

Vaccine Infographic by Leon Farrant.

I often speak with patients who tell me that they do not wish to be vaccinated because they do not see the point, that it is a farce, that it can cause autism (it does not), despite educating and informing them of the reasons behind it. 

In the same way that people who did not grow up during the great wars of the mid-twentieth century have little frame of reference as to what the toll of total war can be, neither can a newer generation of people who have never seen the effects of polio, smallpox, and measles ravage humanity. For many people in the developed world, these are just distant, faded memories captured in the pages of medical textbooks. 

I sincerely hope that the understanding of why we vaccinate does not become lost over time, that people need not fall victim to these preventable diseases; otherwise, the suffering, the challenges, and the research that went into developing these vaccines were all for nothing.

protestants: god is not an absent father! talk to god like a friend! god is always with you! bring your problems to god, no matter how small! it’s not at all weird to call god “daddy!”

catholics: god is far too important to give a fuck about your lost keys or your algebra exam. please address your petty concerns to one of god’s ten thousand holy secretaries. if it’s really important, consider asking his mom.

Recognising silent acute pain in animals - assorted species grimace scales:

Development of the Horse Grimace Scale (HGS) as a Pain Assessment Tool in Horses Undergoing Routine Castration 

The composition and initial evaluation of a grimace scale in ferrets after surgical implantation of a telemetry probe 

The Assessment of Facial Expressions in Piglets Undergoing Tail Docking and Castration: Toward the Development of the Piglet Grimace Scale 

The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep and the  Coding and quantification of a facial expression for pain in lambs 

Mouse -  How to be a pain management advocate for exotic and zoo animals (full text available - includes additional species)

The Rat Grimace Scale: A partially automated method for quantifying pain in the laboratory rat via facial expressions 

Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses 

Pain evaluation in dairy cattle 

Pain is subtle - we cannot depend on vocalisations or extreme abnormal behaviour to determine if an animal is on pain - animals can cover up pain while going about their daily life. Grimace scales have been found to be reliable indicators of pain (full text available)

Unfortunately, I could not find a clear visual grimace scale for dogs, cats or birds :(  

Which is a shame, because perhaps I could have recognised my own dog’s discomfort for the acute pain it was sooner:

(left: dog in pain. See eyes, tension, cheeks, whiskers, ears compared to the multiple species grimace charts above. right: tired but not in pain dog)

Perhaps my new books that arrived today might have some on dogs at least. There’s this visual blog post of a stressed dog at the vet - stress in the absence of a trigger looks very much like pain.

Here is a small comparative cats, with the link going into more detail. Not a scale but better than nothing:

Bonus round - you can get free A3 posters on recognising pain for Rabbits, Mice and Rats from the National Centre for the Replacement, Refinement and Reduction of Animals in Research. My rabbit specialist vet has the rabbit one!

(Image: U. Müeller)

New neurons (in green) are guided to the neocortex  - responsible for controlling language and movement - not by glial cells, but by a protein called reelin.

Journal reference: Neuron, DOI: 10.1016/j.neuron.2011.01.003

Cutaneous mass on the right flank of a 2 year-old, female-spayed, black Labrador Retriever.  The owner noticed the mass approximately a week earlier, and it has been growing in size every day.  On palpation, the lesion was quite painful.  The dog also had a fever, at 103.5°F.

*

Fine needle aspiration revealed copious inflammatory cells.  Mainly neutrophils, with lesser numbers of macrophages.  Notice how some of the neutrophils appear ragged, some borderlining on unidentifiable?  Such changes are consistent with a degenerative change, which usually occurs in the presence of a bacterial agent.  And speaking of bacteria, there are TONS.  A mixed collection of cocci and filamentous rods (red arrow).  The presence of filamentous rods is often associated with plant foreign material (like a ‘grass awn’ or ‘cheat grass’).

*

Diagnosis: Marked, septic, suppurative inflammation with necrosis.  Basically an abscess.  A key piece of history…the patient is a hunting dog and partook in some field trials a few days before the mass developed.  The patient is slated to have the mass surgically explored in hopes of finding planet debris.

“What’s that on the beach?!" 

Monterey Bay beachcombers and divers were treated to a huge bloom of salps this weekend! Salps are gelatinous filter-feeders that drift with and feed in the plankton. Wind and waves sometimes blow these open-ocean emissaries onshore by the thousands, a feast for fishes, invertebrates—and for the eyes of curious naturalists!

There were several species of salps in this weekend’s bloom, including these in the genus Salpa. Salps do not sting—in fact, they’re more closely related to fishes and people than they are to other "jellies”! The brown/orange orb is the salp’s gut. Pumping muscle bands push water from one end of the animal to the other through an internal plankton-pasta strainer.

Salps have an incredibly successful reproductive strategy, allowing them to explode in numbers when conditions are right. Ready? Here we go: Salps can be found as solos, or as a chain of dozens of individuals attached together. Same species, two different body morphs. The solos produce the chain asexually, and the individuals in the chain are all clones. 

OK, still with us? The next part is a doozy: A young chain is female, and each female clone produces another solo salp from an egg that is fertilized by older male chains. The older male chains are female chains that changed sex as they aged—this is called sequential hermaphroditism. This whole process allows salps to produce new generations at an incredible rate, to take advantage of fleeting oceanic conditions. Phew, we did it!

Salps are thought to have an outsized effect on the flow of nutrients in the ocean’s food web. Because their fecal pellets sink, salp poop delivers vital nutrition from the ocean surface to the deep seafloor, and helps take carbon from the atmosphere to the deep, which helps regulate the planet’s climate. Spent salps from these huge blooms become food for countless organisms throughout the water column. Certain deep sea communities may even depend on these ephemeral feasts to survive in the desert of the abyssal plain, according to research by our colleagues at the Monterey Bay Aquarium Research Institute (MBARI).

This weekend’s salp bloom is a jiggly reminder of the vast community of gelatinous drifters—the gelata—that drift in the open ocean, connecting the surface to the deep and adjusting the Earth’s energy flow, unseen by most until a chance encounter on the shore.

Photo: Charles Schrammel Gif: Alison Smith

Nothing spices up your love life like the scientific method!