Guys… I Don’t Know If You Know This But… If You Wake Up Early… There’s So Many More Hours In

guys… I don’t know if you know this but… if you wake up early… there’s so many more hours in the day

Antimicrobial Agents - Cell wall inhibitors

Based on mode of action • divided into families based on chemical structure

Modes of action Interference with:

cell wall synthesis

protein synthesis

nucleic acid synthesis

plasma membrane integrity

metabolic pathway

Inhibitors of Bacterial Cell Wall (peptidoglycan) Synthesis

The Beta-lactam Family

The Glycopeptides

Peptidoglycan is composed of N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) repeat units, and amino acids. Each NAM is linked to peptide chain and the peptide chains are cross-linked.

β-lactams

Includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems.

class of broad-spectrum antibiotics containing a β-lactam ring

Bacterial transpeptidase enzymes are responsible for catalysing cross-linking of the peptide chains

β-lactam ring bind to these transpeptidases – this inhibits cross-linking between peptide chains and prevents synthesis of stable PG

Cell wall synthesis ceases and the bacterial cells eventually die due to osmotic instability or autolysis.

Glycopeptides

Polypeptide agents - basic structural elements amino acids

Vancomycin:

complexes with peptide portion of peptidoglycan’s precursor units

vancomycin is a large hydrophilic molecule able to form hydrogen bonds with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides

preventing PG transglycosylation reaction – PG precursor subunits (NAG-NAM+peptide) cannot be inserted into peptidoglycan matrix;

Vancomycin also alters bacterial-cell-membrane permeability and RNA synthesis

Uses: serious Gram positive infections e.g. MRSA wound infection

Adverse effects:

damage to auditory nerve

hearing loss (ototoxicity)

“Red man/neck” syndrome - rash on face, neck, upper torso

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medintp

4 years ago

Anyway I Had A Really Stupid Idea, Tag Me If You End Up Making A Character/illustration Using This!

anyway i had a really stupid idea, tag me if you end up making a character/illustration using this!

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medintp

6 years ago

If you're tired, read this. Please.

Hey, amigo.

It’s hard, isn’t it?

I know. Sometimes, it’s painful too.

Sometimes you really wanna give up, throw the books, hide in a corner and never take any action again.

I understand. I really do.

But I’m not here to collaborate on the pity party. I’m not going to join in on the groaning challenge, or complain about how hard it is.

First, get this though. It is hard. I won’t lie. It is worth groaning upon. Maybe one or two pity parties are affordable too.

Yet, there’s a pact we’ve make together, and I’d like to remind you of it, before we talk further. New here? We call it the Shush Pact.

Don’t do it. Don’t complain. Don’t whine. Don’t give in so easily. Don’t.

Go ahead. Make the pact. Now.

Go on! Do it.

Tell yourself, today’s hard. Tiring. But, I won’t give in to this. Nor will I complain and moan about it, and waste my energy. Not today, Amelia! Today’s not that day.

Done?

Sure?

Okay. Let’s go.

If you’re tired.

If you’re tired, exhausted of the hustle, and almost at your breaking point, I want you to remember how MUCH this means to you.

I don’t know what’s driving you nuts. Maybe it’s a math problem you just can’t crack. The presentation due next week that isn’t up to the mark. Maybe it’s 3 gigantic books you have to read up on before your next theology class. Perhaps your business has come at a standstill, and you can’t get it to grow. Or maybe you hate your job, and have finally, bravely, taken the step to work the 6 hours after you come home on building the art portfolio of your dreams, because in your heart, you’ve always been an artist. Maybe you’re juggling three jobs and working late nights to save enough money to catch the dream bus.

I don’t know. But I do know that it means a lot to you.

I know how passionate you’re about this, and how much it means to you.

And yet, you’re tired.

You’re tired of it!

You’re tired of studying so much. You’re tired of DMing every business in town, to have none reply back. You’re tired of working so much, handling so much, and you feel like you haven’t had a break since you were a kid. You’re tired of the pressure, you’re tired of the hustle and you just… wanna quit.

Don’t.

Please.

It’s hard to be positive in this dark, numb time and you’re starting to work mechanically, questioning your existence with every hour, but I have to make you understand! You’re worth this! You’re so worthy of this, my love.

Please don’t quit.

Don’t give up. It’s hard, but seal those lips, and trust your gut. I know you can make it. You’ve worked so hard for this! You’ve struggled so much, invested in so many weeks of work, and right now, at your breaking point, I want you to realise that you’re worthy. Of getting that grade, that degree, finding a job you love, your crazy ambitions of opening a flower shop… everything! All of it!

You deserve the world.

Listen to me. Open your ear and listen: you’re tired, yes. But here’s the truth. You’re not done yet.

You’ve got so much to prove to yourself. So many identities to identify yourself with. Exams to slay, jobs to get, money to make, dreams to build, people to meet and love to spread.

Listen. There’s more to this. There’s more to YOU.

Don’t give up now.

Not today.

You’re not done yet.

Tiredness will pass, and I want you to just try pushing through this. Just try. You’ll see you’re so capable of winning and it’ll blow your mind when you look back and realise the strength you truly possessed because you were able to push through.

Winning is your blood. It’s your oxygen.

Tiredness is a toxic. A poison. You’re not tired, you just think you are. When the human brain says it’s done, it’s actually got 70% more to give.

Don’t forget. Your legacy awaits. If this truly means everything to you, if you’ve already put in hundreds of hours of work into this, PUSH THROUGH! You’ve got to, because your future self deserves a better life! Don’t let them tell you that you need a break. A Hawaii vacation. They’ll say you’re getting nowhere and urge you to take a break.

You and me, we both know you don’t need one. You just needed a reminder of your capabilities.

And I’ve given you that now.

Just remember, you’re not done yet.

So fuck tiredness.

Go win.

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medintp

6 years ago

are you a pink lemonade gay or a vanilla coke gay? sword gay or axe gay? cats and dogs gay or snakes and lizards gay? string lights gay or neon lights gay?

The Night Before a Big Exam.

long time no text post huh?

For all my new followers, hello I’m Nadine I’m 23 years old and I’m finishing my fifth year in medschool where I go it’s six years right after high school. And a few days ago y’all probably saw me freaking out the night before a big test.

I was panicking so much because that teacher is notorious for his larger than life exams and surgery really isn’t my forte here but I just got my results back, they were very interesting and they led me to an important conclusion that I wanna share with you. Let me break it down first

I had all of my guides ready (here is a post on how I make them) and for the week before my exam I was studying consistently (so reading my guides in the morning and doing some MCQs at night). Mind you I usually only do one study session per day but I’d really pushed myself this time and as I was going to bed 2 days before my test I had finished 19 out of the 25 topics I needed to get done.

So when I woke up the next day (24 hours till major squashfest test) I felt literally sick, my head was hurting really bad, I believe it was a tension headache, self diagnosis I mean I’m almost a doctor right, and I got my period and we all know how awful that first day is. My original plan was to go over the 6 VERY little chapters I had left (as I mentioned in my how to study for finals post I usually start with what I know least/the hardest chapters and leave the easier and shorter stuff towards the end, a strategy I fucking swear by) so my plan was to get these done in 4 hours or so and then revise for the whole day.

Obviously things did not go according to plan because I was having a terrible headache + all of your standard first day of period shit and I was only able to get these 6 little chapters done by 12 am that night (so 8 hours till the godforsaken test).

I woke up the day of the test, got ready and went to uni and I kid you not I have never been so fucking terrified in my life over an exam because I usually take comfort in the fact that I had done my best and literally for those past 24 hours I had only gotten in 3.5 hours of very mediocre studying and there were some things that I had last went over a week ago (!!), how the hell am I gonna remember them was the only thing on my mind the entire day. I was so exhausted from pushing myself so hard all week plus my period and it was all too much.

Fast forward a few hours later, exam done, I felt horrible afterwards, I thought I was going to fail so I just took a looooong ass nap and then woke up and got myself a chocolate frap. Then I got my results and I actually had done pretty well. 87% is not my best but it’s a fucking good grade and I was so proud.

So where’s the lesson here

IT IS NOT JUST ABOUT THAT ONE NIGHT BEFORE AN EXAM. It’s honestly something I’ve believed in my entire life, the night before a big test you just revise revise revise until you go to bed, you wake up and revise revise revise until you’re inside the exam hall, that’s just how it’s been for me my entire life and this experience taught me that it’s okay if you don’t get a chance to go over everything the night before a test and as long as you’ve put in the work at some point and get plenty of sleep you should be good to go. I’ve said it before and I’ll say it again all nighters are THE DEVIL they do not work they just fuck you up. So yeah, let’s all try and not be so hard on ourselves the night before an exam, take it from me if you’ve put in the work just get enough sleep and you’re good. One night did not cancel out a week of hard work for me and I’m sure it won’t for you. Take it from someone who’s been there, just go to bed.

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medintp

6 years ago

The International Space Station: Apex of International Collaboration

It’s National Space Day! To mark the occasion, we’re reflecting on the International Space Station, which has been continuously occupied since Nov. 2, 2000. As our orbiting laboratory that enables us to conduct important science off our home planet, the ISS allows researchers from all over the world to put their talents to work on innovative experiments in the microgravity environment. An international partnership of space agencies provides and operates the elements of the ISS. The principals are the space agencies of the United States, Russia, Europe, Japan and Canada. Although each space station partner has distinct agency goals for station research, each partner shares a unified goal to extend the resulting knowledge for the betterment of humanity! Here are 5 fun facts about our about our out-of-this world floating laboratory: