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Is greaser sans and Fresh canon?
I'm not sure really, depends on what you define as canon. CQ has roleplayed the ship with Radsee (creator of Greaser, formerly went by Rodsee) and enjoys it, but she's also said "It's so out of character for Fresh to have a relationship. period" about a different ship, after the Freshgrease ship was popularized.
Hope that helps! I see the ship as a What-If scenario, being if Fresh was ever able to develop feelings and cope with them, he may fall for Greaser... Basically a looong string of roleplays is what got Fresh there.(It's also a crush that nobody would expect to happen, because Greaser is an alcoholic smoker and Fresh is STRICTLY against drugs and alcohol to an extreme extent) but in Fresh's default state, the Fresh most people know, he wouldn't fall for anyone because he's incapable of love.
Here's a post CQ made about it to give better context
Also since I haven't gotten to see the roleplays myself, I don't know if they ever got together, all I know is that Fresh had a crush on Greaser in that roleplay and Greaser was terrified of being loved because he sees himself as a detriment to other people