Curate, connect, and discover
I firmly believe that Wilson is aromantic, but he hasn't realized and that's why all his romantic relationships fail. He's got this I can fix them mentality that's why he gets with needy/broken people. He feels sorry for them, he feels empathy and compassion for them, which he mistakes for romantic attraction, and he is sexually attracted to them so he enters a romantic relationship. But when his compassion wears out and he gets burned out from all the emotional labour there's nothing left to sustain the bond (except I guess sexual attraction but I know nothing about that since I'm ace) so the relationship fails.
That's also why I love him and House as a QPR. I know many people ship them romantically but I don't think that would work out for them very well. (House would be the first ex-husband XD)
I don't know if it makes sense, and I yet have to figure out how Amber fits into this headcanon but whatever...