Curate, connect, and discover
fun little danny phantom headcanon i came up with recently is, since the functionality of ectoplasm is mostly in fanon, i think that despite it technically being a biohazard in long amounts of direct exposure, just like, touching it won't cause any lasting harm. until you apply an electrical charge to it, then it becomes volatile to harm even living people. meaning if you put a source of electricity in an ecto-weapon, instead of just firing the ectoplasm itself, that shit'll hurt.
ghosts naturally carry some sort of charge in them at all times (their core i guess?) to power/trigger their attacks, with the more charge in them, the stronger their attacks are to both dead and living. the ghost zone itself is highly charged as well, making it dangerous for humans to wander around for long amounts of time without protection, but as it leaks out the portal, the charge dissipates into the air leaving it as just ambient ectoplasm and totally harmless.
so combine the high charge of the infinite realms with the probably millions of volts of electricity needed to power a portal to the land of the dead and well... :)