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This. This was houses love confession.
Throughout the whole show there have been themes of characters reflecting their problems onto patients and talking about the patient when they're actually talking about themselves.
House - the one uncomfortable with human emotions like love - making a conversation that was heading to talking about Wilsons feelings, into a joke that is even more steered towards love and whatnot.
Maybe, house just randomly decided to make a gay joke in a very tender moment before starting a treatment that might kill his best friend, you know, a moment where you might... confess something.
Or he finally said i love you without actually having to. In this essay i will-