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Apply independently produced drug to the burnt area

Fed Up With Drug Companies, Hospitals Decide to Start Their Own

"A group of large hospital systems plans to create a nonprofit generic drug company to battle shortages and high prices.

Researchers develop ‘self-healing’ robotics material

Image: Victor Habbick Visions/Science Photo Library

Traditional electronics are made from rigid and brittle materials. However, a new ‘self-healing’ electronic material allows a soft robot to recover its circuits after it is punctured, torn or even slashed with a razor blade.

Made from liquid metal droplets suspended in a flexible silicone elastomer, it is softer than skin and can stretch about twice its length before springing back to its original size.

Soft Robotics & Biologically Inspired Robotics at Carnegie Mellon University. Video: Mouser Electronics 

‘The material around the damaged area automatically creates new conductive pathways, which bypass the damage and restore connectivity in the circuit,’ explains first author Carmel Majidi at Carnegie Mellon University in Pittsburgh, Pennsylvania. The rubbery material could be used for wearable computing, electronic textiles, soft field robots or inflatable extra-terrestrial housing.

‘There is a sweet spot for the size of the droplets,’ says Majidi. ‘We had to get the size not so small that they never rupture and form electronic connections, but not so big they would rupture even under light pressure.’

To read the full article, by Anthony King, in C&I, the members’ magazine for SCI, click here. 

Flame Nebula in Orion - For more images of the cosmos Click Here

Tumour Markers

Chemical biomarkers that can be elevated by the presence of one or more types of cancer,  produced directly by the tumour or by non-tumour cells as a response to the presence of a tumour. Really great tests as can use just blood/urine, but aren’t the most specific and false positives do occur.

Alpha-fetoprotein (AFP) 

Glycoprotein synthesised in yolk sac, the foetal liver, and gut - will be high in a foetus and during pregnancy. 

<10 ng/mL is normal for adults

>500 ng/mL could indicate liver tumour

Normally:

Produced primarily by the liver in a developing foetus 

Thought to be a foetal form of albumin

suppress lymphocyte activation and antibody production in adults (immune suppressant)

Binds bilirubin, fatty acids, hormones and metals

In cancer:

Detects hepatocarcinoma (liver cancer)

Risk factors: haemochromotosis, hep B, alcoholism - cell repair and growth from this damage leads to cancers

Present in non-pathogenic liver proliferation, including the growth and repair response to the above. This makes it hard to differentiate - AFP levels can be raised in patients with liver cancer risk factors due to the factors themselves, not a cancer. Not very diagnostic!! Used in combination with other tests/factors. Sensitivity and specificity ~75%

Other hepatocellular carcinoma markers:

γGT (γ-glutamyltransferase) - biliary damage

AFP mRNA (not always together with AFP! Might not be activated)

γGT mRNA elevated

Raised cytokines (IL-8, VEGF, TGF-B1) 

ALT and AST elevated - liver disease

Carcinoembryonic antigen (CEA)

a set of highly related glycoproteins involved in cell adhesion. Potentially associated with innate immune system.

Normally:

produced in gastrointestinal tissue during foetal development 

production stops before birth

present only at very low levels in the blood of healthy adults. 

Cancer:

Elevated in almost all patients with colorectal cancer

Can monitor recurrence of cancer (when compared to previous test results for that patient) with a sensitivity of 80% and specificity of 70%

levels may also be raised in gastric, pancreatic, lung, breast and medullary thyroid carcinomas

also some non-neoplastic (not cancer) conditions like ulcerative colitis, liver disease, pancreatitis,  COPD, Crohn’s disease, hypothyroidism - again, high risk groups for colorectal cancer - not a diagnostic test

Levels elevated in smokers.

Carbohydrate antigens (CA)

Including:

CA 19-9 - Pancreas

CA 15-3 Breast

CA 50 - Colorectal

CA 125 - ovarian

Levels rise only in disease states and particularly cancer, but will not rise in all patients.

Part 2 coming soon!

Sound metal, don't you think?

Engineers 3-D print high-strength aluminum, solve ages-old welding problem using nanoparticles

HRL Laboratories has made a breakthrough in metallurgy with the announcement that researchers at the famous facility have developed a technique for successfully 3D printing high-strength aluminum alloys—including types Al7075 and Al6061—that opens the door to additive manufacturing of engineering-relevant alloys. These alloys are very desirable for aircraft and automobile parts and have been among thousands that were not amenable to additive manufacturing—3D printing—a difficulty that has been solved by the HRL researchers. An added benefit is that their method can be applied to additional alloy families such as high-strength steels and nickel-based superalloys difficult to process currently in additive manufacturing.

“We’re using a 70-year-old nucleation theory to solve a 100-year-old problem with a 21st century machine,” said Hunter Martin, who co-led the team with Brennan Yahata. Both are engineers in the HRL’s Sensors and Materials Laboratory and PhD students at University of California, Santa Barbara studying with Professor Tresa Pollock, a co-author on the study. Their paper 3D printing of high-strength aluminum alloys was published in the September 21, 2017 issue of Nature.

Additive manufacturing of metals typically begins with alloy powders that are applied in thin layers and heated with a laser or other direct heat source to melt and solidify the layers. Normally, if high-strength unweldable aluminum alloys such as Al7075 or AL6061 are used, the resulting parts suffer severe hot cracking—a condition that renders a metal part able to be pulled apart like a flaky biscuit.

Read more.

Cracking eggshell nanostructure: New discovery could have important implications for food safety

How is it that fertilized chicken eggs manage to resist fracture from the outside, while at the same time, are weak enough to break from the inside during chick hatching? It’s all in the eggshell’s nanostructure, according to a new study led by McGill University scientists.

The findings, reported today in Science Advances, could have important implications for food safety in the agro-industry.

Birds have benefited from millions of years of evolution to make the perfect eggshell, a thin, protective biomineralized chamber for embryonic growth that contains all the nutrients required for the growth of a baby chick. The shell, being not too strong, but also not too weak (being “just right” Goldilocks might say), is resistant to fracture until it’s time for hatching.

But what exactly gives bird eggshells these unique features?

To find out, Marc McKee’s research team in McGill’s Faculty of Dentistry, together with Richard Chromik’s group in Engineering and other colleagues, used new sample-preparation techniques to expose the interior of the eggshells to study their molecular nanostructure and mechanical properties.

Read more.

Breakthrough in blending metals—precise control of multimetallic one-nanometer cluster formation achieved

Researchers in Japan have found a way to create innovative materials by blending metals with precision control. Their approach, based on a concept called atom hybridization, opens up an unexplored area of chemistry that could lead to the development of advanced functional materials.

Multimetallic clusters—typically composed of three or more metals—are garnering attention as they exhibit properties that cannot be attained by single-metal materials. If a variety of metal elements are freely blended, it is expected that as-yet-unknown substances are discovered and highly-functional materials are developed. So far, no one had reported the multimetallic clusters blended with more than four metal elements so far because of unfavorable separation of different metals. One idea to overcome this difficulty is miniaturization of cluster sizes to one-nanometer scale, which forces the different metals to be blended in a small space. However, there was no way to realize this idea.

Read more.

Engineers Develop New Manufacturing Process That Spools Out Strips of Graphene

MIT engineers have developed a continuous manufacturing process that produces long strips of high-quality graphene.

The team’s results are the first demonstration of an industrial, scalable method for manufacturing high-quality graphene that is tailored for use in membranes that filter a variety of molecules, including salts, larger ions, proteins, or nanoparticles. Such membranes should be useful for desalination, biological separation, and other applications.

“For several years, researchers have thought of graphene as a potential route to ultrathin membranes,” says John Hart, associate professor of mechanical engineering and director of the Laboratory for Manufacturing and Productivity at MIT. “We believe this is the first study that has tailored the manufacturing of graphene toward membrane applications, which require the graphene to be seamless, cover the substrate fully, and be of high quality.”

Read more.

Solar powered sea slugs shed light on search for perpetual green energy

The sea slug, Elysia chlorotica, steals millions of green-colored plastids, which are like tiny solar panels, from algae. Credit: Karen N. Pelletreau/University of Maine

A Northeast sea slug sucks raw materials from algae to provide its lifetime supply of solar-powered energy, according to a study by Rutgers University-New Brunswick, USA.

‘It’s a remarkable feat because it’s highly unusual for an animal to behave like a plant and survive solely on photosynthesis,’ said Debashish Bhattacharya, senior author of the study and professor in the Department of Biochemistry and Microbiology at Rutgers-New Brunswick. ‘The broader implication is in the field of artificial photosynthesis. That is, if we can figure out how the slug maintains stolen, isolated plastids to fix carbon without the plant nucleus, then maybe we can also harness isolated plastids for eternity as green machines to create bioproducts or energy. The existing paradigm is that to make green energy, we need the plant or alga to run the photosynthetic organelle, but the slug shows us that this does not have to be the case.’

The sea slug Elysia chlorotica, a mollusk that can grow to more than 2 inches long, has been found in the intertidal zone between Nova Scotia, Canada, and Martha’s Vineyard, Massachusetts, as well as in Florida. Juvenile sea slugs eat the nontoxic brown alga Vaucheria litorea and become photosynthetic – or solar-powered – after stealing millions of algal plastids, which are like tiny solar panels, and storing them in their gut lining, according to the study published online in the journal Molecular Biology and Evolution.

This particular alga is an ideal food source because it does not have walls between adjoining cells in its body and is essentially a long tube loaded with nuclei and plastids, Bhattacharya said. ‘When the sea slug makes a hole in the outer cell wall, it can suck out the cell contents and gather all of the algal plastids at once,’ he said.

Read the full study here: Cheong Xin Chan, Pavel Vaysberg, Dana C Price, Karen N Pelletreau, Mary E Rumpho, Debashish Bhattacharya. Active Host Response to Algal Symbionts in the Sea Slug Elysia chlorotica. Molecular Biology and Evolution, 2018; DOI: 10.1093/molbev/msy061

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