Engineers Develop New Manufacturing Process That Spools Out Strips Of Graphene

““One of the holy grails of biomaterials research has been working out a way to get skin to grow onto and attach to metals and plastics without the risk of infection. It looks like this design and technique may have solved the problem,” says Dr Stynes, who is researching his PhD at the University of Melbourne. “It could pave the way for fully implantable robotics, prosthetics, catheters, intravenous lines, and the reconstruction of surgical defects with artificial materials.” Professor Richard Page, Director of Orthopaedics and the Centre of Orthopaedic Research and Education at Barwon Health and Deakin University, said the ability of the scaffold to make the skin think it was growing on other skin is potentially a major finding.”

— Breaking the Skin Barrier Can Lead to Breakthroughs in Robotics to Human Interface

Pangea fun

lab was fun today

I need some C - H - O - CO late

My friend just sent me this so y'all have to suffer too

Self-healing material a breakthrough for bio-inspired robotics

Many natural organisms have the ability to repair themselves. Now, manufactured machines will be able to mimic this property. In findings published this week in Nature Materials, researchers at Carnegie Mellon University have created a self-healing material that spontaneously repairs itself under extreme mechanical damage.

This soft-matter composite material is composed of liquid metal droplets suspended in a soft elastomer. When damaged, the droplets rupture to form new connections with neighboring droplets and reroute electrical signals without interruption. Circuits produced with conductive traces of this material remain fully and continuously operational when severed, punctured, or had material removed.

Keep reading

Tumour Markers

Chemical biomarkers that can be elevated by the presence of one or more types of cancer,  produced directly by the tumour or by non-tumour cells as a response to the presence of a tumour. Really great tests as can use just blood/urine, but aren’t the most specific and false positives do occur.

Alpha-fetoprotein (AFP) 

Glycoprotein synthesised in yolk sac, the foetal liver, and gut - will be high in a foetus and during pregnancy. 

<10 ng/mL is normal for adults

>500 ng/mL could indicate liver tumour

Normally:

Produced primarily by the liver in a developing foetus 

Thought to be a foetal form of albumin

suppress lymphocyte activation and antibody production in adults (immune suppressant)

Binds bilirubin, fatty acids, hormones and metals

In cancer:

Detects hepatocarcinoma (liver cancer)

Risk factors: haemochromotosis, hep B, alcoholism - cell repair and growth from this damage leads to cancers

Present in non-pathogenic liver proliferation, including the growth and repair response to the above. This makes it hard to differentiate - AFP levels can be raised in patients with liver cancer risk factors due to the factors themselves, not a cancer. Not very diagnostic!! Used in combination with other tests/factors. Sensitivity and specificity ~75%

Other hepatocellular carcinoma markers:

γGT (γ-glutamyltransferase) - biliary damage

AFP mRNA (not always together with AFP! Might not be activated)

γGT mRNA elevated

Raised cytokines (IL-8, VEGF, TGF-B1) 

ALT and AST elevated - liver disease

Carcinoembryonic antigen (CEA)

a set of highly related glycoproteins involved in cell adhesion. Potentially associated with innate immune system.

Normally:

produced in gastrointestinal tissue during foetal development 

production stops before birth

present only at very low levels in the blood of healthy adults. 

Cancer:

Elevated in almost all patients with colorectal cancer

Can monitor recurrence of cancer (when compared to previous test results for that patient) with a sensitivity of 80% and specificity of 70%

levels may also be raised in gastric, pancreatic, lung, breast and medullary thyroid carcinomas

also some non-neoplastic (not cancer) conditions like ulcerative colitis, liver disease, pancreatitis,  COPD, Crohn’s disease, hypothyroidism - again, high risk groups for colorectal cancer - not a diagnostic test

Levels elevated in smokers.

Carbohydrate antigens (CA)

Including:

CA 19-9 - Pancreas

CA 15-3 Breast

CA 50 - Colorectal

CA 125 - ovarian

Levels rise only in disease states and particularly cancer, but will not rise in all patients.

Part 2 coming soon!

Researchers develop ‘self-healing’ robotics material

Image: Victor Habbick Visions/Science Photo Library

Traditional electronics are made from rigid and brittle materials. However, a new ‘self-healing’ electronic material allows a soft robot to recover its circuits after it is punctured, torn or even slashed with a razor blade.

Made from liquid metal droplets suspended in a flexible silicone elastomer, it is softer than skin and can stretch about twice its length before springing back to its original size.

Soft Robotics & Biologically Inspired Robotics at Carnegie Mellon University. Video: Mouser Electronics 

‘The material around the damaged area automatically creates new conductive pathways, which bypass the damage and restore connectivity in the circuit,’ explains first author Carmel Majidi at Carnegie Mellon University in Pittsburgh, Pennsylvania. The rubbery material could be used for wearable computing, electronic textiles, soft field robots or inflatable extra-terrestrial housing.

‘There is a sweet spot for the size of the droplets,’ says Majidi. ‘We had to get the size not so small that they never rupture and form electronic connections, but not so big they would rupture even under light pressure.’

To read the full article, by Anthony King, in C&I, the members’ magazine for SCI, click here. 

The end of heartless b*tches

Swiss scientists just 3D printed an artificial heart that beats like the real thing

Scientists at Switzerland’s ETH Zurich have used 3D printing to create a functional beating heart made of silicone. Here's why.

This realistic 3D-printed silicon heart could help people in need of heart transplants when there are not enough donors.

Don't drink dihydrogen monoxide. Everybody dies who does!

Dihydrogen Monoxide Bottle

Skin gel allows wounds to heal without leaving a scar

A team of researchers at Huazhong University of Science and Technology has developed a silk protein-based gel that they claim allows for skin healing without scarring. In their paper published in the journal Biomaterials Science, the group describes their gel and how well it works.

Scarring due to a skin injury is not just unsightly—for many, it can also be a painful reminder of a wound. For these reasons, scientists have sought a way to heal wounds without scarring. In this new effort, the team in China claims to have found such a solution—a sericin hydrogel.

The gel used by the researchers was based on a silk protein—the researchers extracted sericin from silk fibers and then used a UV light and a photoinitiator to cross-link the protein chains. The result was a gel that adhered well to cells and did not trigger much of an immune response. The researchers note that it also has adjustable mechanical properties. They explain that the gel allows for scar-free healing by inhibiting inflammation and by promoting the development of new blood vessels. It was also found to regulate TGF-β growth factors, which resulted in stem cells being routed to the injury site allowing new skin to develop, rather than scar tissue.

Read more.

LISTEN UP YALL

scientists are saying we have about three years before all climate change effects are completely irreversible (meaning we are absolutely FUCKED). that’s just to avoid the worst of it (yes, all this shit with the fires and hurricanes is NOT the worst of it). so, i made a quick list of things people can do to start reducing their energy use and in turn, reducing greenhouse gas emissions and what not! -line/hang dry clothing - dryers use so much energy as it is and switching to the actually makes your clothing last so much longer! aka less energy spent on manufacturing and shipping clothing. -eat less meat - when i say this, it’s not specifically for the save the animals idea, but that is a huge bonus! factories that slaughter, process, and package meat use an insane amount of energy (another reason to switch to local as much as possible!!) -use less hot water - wash clothes in cold water, take shorter showers (or cold ones if you can handle that) -switch to reusable grocery bags -efficient light bulbs -carpool, walk, ride a bike, public transit -unplug electronics not in use - don’t leave things charging for too long. unplug your tv when it’s not being used. 40% of an item’s energy use is spent when it’s on standby!! -buy only what you need (look into minimalism guys, it’s real neat and saves money) -recycle -get a reusable water bottle instead of buying cases of plastic bottles - i bought one at walmart for 98 cents and i use it every single day. -plant your own garden or start a community garden! -composting -maintain air in car tires for better gas mileage -drive instead of taking airplanes -buy used items if they’re in good condition - why spend $20 on a shirt that you can find at goodwill for $1? same goes for books, CDs, and pretty much anything! save money AND cut down on energy use! -yall know that saying “reduce, reuse, recycle” -most importantly: TALK TO PEOPLE ABOUT THIS ISSUE - i mean your friends, your family, your local government, everyone!! these are all small things and it’s just a start but if we can get everyone in on habits like these, we could reduce the population’s carbon footprint by SO MUCH! we don’t wanna end up like that movie wall-e guys. this is serious!!