ISS Expedition 54 Crew Land Safely In Kazakhstan

A woman in Nevada dies from a bacterial infection that was resistant to 26 different antibiotics. A U.K. patient contracts a case of multidrug-resistant gonorrhea never seen before. A typhoid superbug kills hundreds in Pakistan. These stories from recent years — and many others — raise fears about the possibility of a post-antibiotic world.

The development of antibiotics in the early 20th century was one of the greatest leaps forward of modern medicine. Suddenly, common illnesses like pneumonia, strep throat and gonorrhea were no longer potential death sentences.

But even in the infancy of antibiotics, it was clear that their misuse and overuse could lead to antibiotic resistance and eventually create untreatable superbugs.

In this video, we explain how antibiotic resistance happens — and what we can do to avoid living in a post-antibiotic world.

Video: NPR

Researchers develop ‘self-healing’ robotics material

Image: Victor Habbick Visions/Science Photo Library

Traditional electronics are made from rigid and brittle materials. However, a new ‘self-healing’ electronic material allows a soft robot to recover its circuits after it is punctured, torn or even slashed with a razor blade.

Made from liquid metal droplets suspended in a flexible silicone elastomer, it is softer than skin and can stretch about twice its length before springing back to its original size.

Soft Robotics & Biologically Inspired Robotics at Carnegie Mellon University. Video: Mouser Electronics 

‘The material around the damaged area automatically creates new conductive pathways, which bypass the damage and restore connectivity in the circuit,’ explains first author Carmel Majidi at Carnegie Mellon University in Pittsburgh, Pennsylvania. The rubbery material could be used for wearable computing, electronic textiles, soft field robots or inflatable extra-terrestrial housing.

‘There is a sweet spot for the size of the droplets,’ says Majidi. ‘We had to get the size not so small that they never rupture and form electronic connections, but not so big they would rupture even under light pressure.’

To read the full article, by Anthony King, in C&I, the members’ magazine for SCI, click here. 

(via MIT researchers turn water into ‘calm’ computer interfaces)

…The Tangible Media Group demonstrated a way to precisely transport droplets of liquid across a surface back in January, which it called “programmable droplets.” The system is essentially just a printed circuit board, coated with a low-friction material, with a grid of copper wiring on top. By programmatically controlling the electric field of the grid, the team is able to change the shape of polarizable liquid droplets and move them around the surface. The precise control is such that droplets can be both merged and split.

Moving on from the underlying technology, the team is now focused on showing how we might leverage the system to create, play and communicate through natural materials…

Re-generatively cooled RL10 Thrust Chamber Assembly test validates 3D printing process

West Palm Beach FL (SPX) Jun 18, 2018 Aerojet Rocketdyne recently achieved a significant milestone by successfully completing a series of hot-fire tests of an advanced, next-generation RL10 engine thrust chamber design that was built almost entirely using additive manufacturing; commonly known as 3-D printing. “This recent series of hot-fire tests conducted under our RL10C-X development program demonstrated the large-scale add Full article

Tumour Markers

Chemical biomarkers that can be elevated by the presence of one or more types of cancer,  produced directly by the tumour or by non-tumour cells as a response to the presence of a tumour. Really great tests as can use just blood/urine, but aren’t the most specific and false positives do occur.

Alpha-fetoprotein (AFP) 

Glycoprotein synthesised in yolk sac, the foetal liver, and gut - will be high in a foetus and during pregnancy. 

<10 ng/mL is normal for adults

>500 ng/mL could indicate liver tumour

Normally:

Produced primarily by the liver in a developing foetus 

Thought to be a foetal form of albumin

suppress lymphocyte activation and antibody production in adults (immune suppressant)

Binds bilirubin, fatty acids, hormones and metals

In cancer:

Detects hepatocarcinoma (liver cancer)

Risk factors: haemochromotosis, hep B, alcoholism - cell repair and growth from this damage leads to cancers

Present in non-pathogenic liver proliferation, including the growth and repair response to the above. This makes it hard to differentiate - AFP levels can be raised in patients with liver cancer risk factors due to the factors themselves, not a cancer. Not very diagnostic!! Used in combination with other tests/factors. Sensitivity and specificity ~75%

Other hepatocellular carcinoma markers:

γGT (γ-glutamyltransferase) - biliary damage

AFP mRNA (not always together with AFP! Might not be activated)

γGT mRNA elevated

Raised cytokines (IL-8, VEGF, TGF-B1) 

ALT and AST elevated - liver disease

Carcinoembryonic antigen (CEA)

a set of highly related glycoproteins involved in cell adhesion. Potentially associated with innate immune system.

Normally:

produced in gastrointestinal tissue during foetal development 

production stops before birth

present only at very low levels in the blood of healthy adults. 

Cancer:

Elevated in almost all patients with colorectal cancer

Can monitor recurrence of cancer (when compared to previous test results for that patient) with a sensitivity of 80% and specificity of 70%

levels may also be raised in gastric, pancreatic, lung, breast and medullary thyroid carcinomas

also some non-neoplastic (not cancer) conditions like ulcerative colitis, liver disease, pancreatitis,  COPD, Crohn’s disease, hypothyroidism - again, high risk groups for colorectal cancer - not a diagnostic test

Levels elevated in smokers.

Carbohydrate antigens (CA)

Including:

CA 19-9 - Pancreas

CA 15-3 Breast

CA 50 - Colorectal

CA 125 - ovarian

Levels rise only in disease states and particularly cancer, but will not rise in all patients.

Part 2 coming soon!

NASA eyes versatile carbon-nanotube technology for spaceflight applications

An ultra-dark coating comprised of nearly invisible shag rug-like strands made of pure carbon is proving to be highly versatile for all types of spaceflight applications.

In the most recent application of the carbon-nanotube coating, optical engineer John Hagopian, a contractor at NASA’s Goddard Space Flight Center in Greenbelt, Maryland, and Goddard scientist Lucy Lim are growing an array of miniscule, button-shaped bumps of multi-walled nanotubes on a silicon wafer.

The dots, which measure only 100 microns in diameter—roughly the size of a human hair—would serve as the “ammunition” source for a mini-electron probe. This type of instrument analyzes the chemical properties of rocks and soil on airless bodies, like the Moon or an asteroid.

Although the probe is still early in its technology development, it’s showing promise, said Lim, who is using funding from NASA’s Planetary Instrument Concepts for the Advancement of Solar System Observations Program, better known as PICASSO, to advance the concept.

Read more.

Origami, 3D printing merge to make complex structures in one shot

By merging the ancient art of origami with 21st century technology, researchers have created a one-step approach to fabricating complex origami structures whose light weight, expandability, and strength could have applications in everything from biomedical devices to equipment used in space exploration. Until now, making such structures has involved multiple steps, more than one material, and assembly from smaller parts.

“What we have here is the proof of concept of an integrated system for manufacturing complex origami. It has tremendous potential applications,” said Glaucio H. Paulino, a professor at the School of Civil and Environmental Engineering at the Georgia Institute of Technology and a leader in the growing field of origami engineering, or using the principles of origami, mathematics and geometry to make useful things. Last fall Georgia Tech became the first university in the country to offer a course on origami engineering, which Paulino taught.

Read more.

‘Junk’ DNA Plays Crucial Role in Holding Genome Together: Study

Jagannathan et al propose that chromocenter and satellite DNA serves a fundamental role in encapsulating the full complement…more Image credit: Lisichik.

Roommate -> roomsister

November 28 2017

Afternoon study session at my university’s library with my astronaut friend @redplanet44 ☆