My PI When She Reads My Writing

Microbiologists have learned how a probiotic bacterium used to treat irritable bowel syndrome can soothe gut bacterial infections caused by salmonella, paving the way for potential relief from foodborne illnesses that affect millions of people annually.

There was a sensitive pragmatic question which needed to be answered, however. To put it bluntly: Was Arya going to be naked on camera? Many cast members have appeared nude on the show, though typically signed on when they were at least 18 years old (and often agreed to nudity as part of their deal). The 22-year-old Williams joined Thrones when she was 11 and has grown up in front of fans. Williams says the showrunners let her decide precisely how much to show. “David and Dan were like: ‘You can show as much or as little as you want,’” Williams says. “So I kept myself pretty private. I don’t think it’s important for Arya to flash. This beat isn’t really about that. And everybody else has already done it on the show, so…”

Still, when it came time to film the encounter, Williams had to be naked-ish on set, and that was a naturally a bit awkward. “In the beginning, everyone was really respectful,” she says. “No one wants to make you feel uncomfortable which kind of makes you feel more uncomfortable, because no one wants to look at anything that they shouldn’t look at which in turn makes you feel like you look awful because everyone is kind of like—” [Williams averts her eyes]. “You want people to act more normal.”

Continues Williams: “Then [the scene] was rushed. We were [directed by] David Nutter, who has a habit of speaking fast anyway. By the end we’re rushing to finish the scene and David is going, ‘Okay, you’re going to come in and do this and do that and, great, take your top off’ — and then walked off. And I’m like … ‘Okay. Let’s do it.”

Dempsie suggested the experience was strange for him too for given how long he’s known Williams, who’s about a decade younger than him. “It’s obviously slightly strange for me because I’ve known Maisie since she was 11, 12 years old,” says the 31-year-old actor. “At the same time, I don’t want to be patronizing toward Maisie — she’s a 20-year-old woman. So we just had a lot of fun with it.”

But Williams says what’s most important to her about Arya’s battle-eve night of romance wasn’t reading the scene or even filming it, but rather what this moment meant for her character. Year after year, Arya has been laser-focused on survival and training and revenge. Being with Gendry meant that, for one night at least, Arya had an experience that put her back in touch with her humanity.

“It was really interesting because it’s a very human relationship for Arya,” Williams says. “This is something she’s stayed away from, an emotion we’ve never really seen her engage with. David and Dan were like, ‘It’s the end of the world, what else would you have her do?’ This may be is a moment where Arya accepts death tomorrow, which she never does — ‘Not Today.’ So it was that moment where she says, ‘We’re probably going to die tomorrow, I want to know what this feels like before that happens.’ It’s interesting to see Arya be a bit more human, speak more normally about things people are scared of.” — Maisie Williams discusses Arya’s surprise Gendry scene

Hematopoietic stem cells ready for re-injection. Image from Steve Gschmeisserner.

Right lateral thoracic wall mass from a 10 year-old, female-spayed, Golden Retriever.  Approximately six months ago the owner noticed a small, firm swelling on the patient’s right chest.  No doubt it grew with time, as it finally got large enough for the owner to become truly concerned!  The patient is clinically healthy otherwise.

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The most prominent feature on the cytology were these gorgeous globules of magenta, streaming material!  In fact, the entire slide was imbued with this color when you looked at it without a microscope.  The substance is most likely matrix produced by cancer cells.  Matrix of this color is commonly observed in chrondrosarcomas.  Occasional malignant spindle-shaped cells were found imbedded in the matrix.

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Diagnosis:  Chondrosarcoma.  Well , that’s the most likely diagnosis given the location and appearance of the neoplastic cells and matrix!  Other possibilities include a myxosarcoma (which produces a mucous like material!) or osteosarcoma (malignant primary bone tumor).  Chondrosarcomas are often regionally invasive but rarely metastasize.  If the owner is on board with a chest wall resection, the patient will have  a good prognosis :-)

“What’s that on the beach?!" 

Monterey Bay beachcombers and divers were treated to a huge bloom of salps this weekend! Salps are gelatinous filter-feeders that drift with and feed in the plankton. Wind and waves sometimes blow these open-ocean emissaries onshore by the thousands, a feast for fishes, invertebrates—and for the eyes of curious naturalists!

There were several species of salps in this weekend’s bloom, including these in the genus Salpa. Salps do not sting—in fact, they’re more closely related to fishes and people than they are to other "jellies”! The brown/orange orb is the salp’s gut. Pumping muscle bands push water from one end of the animal to the other through an internal plankton-pasta strainer.

Salps have an incredibly successful reproductive strategy, allowing them to explode in numbers when conditions are right. Ready? Here we go: Salps can be found as solos, or as a chain of dozens of individuals attached together. Same species, two different body morphs. The solos produce the chain asexually, and the individuals in the chain are all clones. 

OK, still with us? The next part is a doozy: A young chain is female, and each female clone produces another solo salp from an egg that is fertilized by older male chains. The older male chains are female chains that changed sex as they aged—this is called sequential hermaphroditism. This whole process allows salps to produce new generations at an incredible rate, to take advantage of fleeting oceanic conditions. Phew, we did it!

Salps are thought to have an outsized effect on the flow of nutrients in the ocean’s food web. Because their fecal pellets sink, salp poop delivers vital nutrition from the ocean surface to the deep seafloor, and helps take carbon from the atmosphere to the deep, which helps regulate the planet’s climate. Spent salps from these huge blooms become food for countless organisms throughout the water column. Certain deep sea communities may even depend on these ephemeral feasts to survive in the desert of the abyssal plain, according to research by our colleagues at the Monterey Bay Aquarium Research Institute (MBARI).

This weekend’s salp bloom is a jiggly reminder of the vast community of gelatinous drifters—the gelata—that drift in the open ocean, connecting the surface to the deep and adjusting the Earth’s energy flow, unseen by most until a chance encounter on the shore.

Photo: Charles Schrammel Gif: Alison Smith

This bad little boy is super rare to find!!!  This is a mitotically active cell present in peripheral blood circulation from a dog - only the second one I have ever seen!!

As a game, in the diagnostic lab we yell KABLAM! anytime we see a mitotic figure.  The first one to say kablam wins :-P  We should so turn it into a drinking game…

My best friend is defending next month, and he has decided to dedicate his thesis to his son and daughter (who are cats) and to his godson (who is my cat). I will never be sad again. This has cured all that ails. 

Sofia Ionescu (1920-2008) was a Romanian neurosurgeon, thought to be one of the first female neurosurgeons in the world.

She studied medicine in Bucharest, and in 1943 became part of the first team of Romanian neurosurgeons. She continued practicing the profession for almost five decades and received numerous awards for her lifesaving work.

Aspirate of a mammary mass from a 8 year-old, female-intact, Yorkshire Terrier.  The patient was found wondering in a field by a good Samaritan-turned-owner over the 4th of July weekend.  Although she was acting normally, the owner brought the little dog in for a ‘look over.’  On physical examination a 2cm mass was felt in the left mammary chain.  No obvious spay scar was present.

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On cytology there were copious clusters of epithelial cells.  These epithelial cells (top picture) were very non-descript, making for large, jumbled piles of cells.  Notice how you cannot see any well-defined cell borders between them?? Just a ton of nuclei (and nucleoli) blending in together!  That’s a sign of cell craziness!  Many clusters were surrounded by this gorgeous, pink-magenta material.  Likely secretory product or matrix.

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Cytologic diagnosis:  Mammary tumor!  Although the cells look quite malignant on cytology, many studies have shown you cannot reliably determine malignancy with cytology alone.  Thus, you NEED a biopsy to determine if a mammary tumor is malignant or benign in a dog.  And flip a coin on that - about 50% are malignant and 50% are benign.  Intact female dogs have an almost 35% lifetime chance of developing one of these beasts!